Qiong Chen1 | Lin Liu2 | Yi Zhang1

1 The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shanghai, China

2 Dermatology Department, Jingfu Medical Beauty Hospital of Chunxi Road Ward, Chengdu, China

Correspondence

Yi Zhang, The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shanghai, China.

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© 2024 The Authors. International Wound Journal published by Medicalhelplines.com Inc and John Wiley & Sons Ltd.

Abstract

Chloasma, which is distinguished by irregularities in the pigmentation of skin, poses substantial challenge in the field of dermatology. The regulatory influence of vitamin D on the functions of skin cells implies that it may have the capacity to effectively treat chloasma and promote wound healing. To assess the efficacy of vitamin D in chloasma treatment and its impact on the function of skin barrier during the process of wound healing. The research spanned from April 2022 to September 2023, in Shanghai, China, examined 480 individuals who had been diagnosed with chloasma. A double-blind, placebocontrolled clinical trial was utilized to evaluate effectiveness of topical vitamin D3 in treatment of chloasma. Concurrently, randomized control trial investigated the effects of ingested vitamin D3 supplements on the process of wound healing. Transepidermal water loss (TEWL), chloasma severity score changes, wound size reduction and skin hydration levels were critical performance indiators. Statistically, the severity scores of chloasma decreased significantly in the vitamin D treatment group at 3 and 6 months compared with the placebo (p < 0.05). The Vitamin D group exhibited superior wound healing outcomes, including more substantial reduction in lesion size and enhanced skin barrier function, as evidenced by increased skin hydration and decreased TEWL (p < 0.05). Vitamin D substantially mitigated the severity of chloasma and has beneficial effect on wound healing and integrity of the skin barrier. Based on the results obtained, vitamin D exhibited promise as a therapeutic intervention in the field of dermatology, specifically in treatment of chloasma and promotion of wound recovery.

KEYWORDS

chloasma treatment, dermatology, skin barrier function, vitamin D, wound healing

Key Messages The study aimed to evaluate the effectiveness of vitamin D in treating chloasma and enhancing wound healing.

Findings revealed that vitamin D significantly reduced chloasma severity and improved wound healing, as indicated by increased skin hydration and decreased transepidermal water loss.