Hongtao Liu, MD1 | Honglai Zheng, MD1 | Siyuan Zhou, MD2 | Quan Lin, MD3
1 Guangxi Health Science College, Nanning, China
2 The Second Affiliated Hospital of Guangxi Medical University, Nanning, China
3 The People's Hospital of Laibin, Laibin, China
Hongtao Liu and Honglai Zheng contributed equally to this work.
Correspondence
Quan Lin, The People's Hospital of Laibin, Laibin 546100, China.
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[Correction added on 26 August 2024, after first online publication:The spelling of the second author’s surname has been corrected in this version.]
Abstract
Background: Aging skin, exacerbated by external factors like UV radiation and pollutants, is a major cosmetic concern. Taurine, renowned for its antioxidant and anti-inflammatory properties, may combat skin aging. We performed mendelian randomization (MR) analysis to investigate the causal link between taurine and immune cells linked to skin aging.
Objectives: To investigate the association between taurine and immune cells using mendelian randomization, to thereby explore the mechanism through which taurine exerts anti-aging effects on the skin via immune modulation.
Methods: A MR approach was employed using taurine-level data from the Ieu Open GWAS Project and immunocyte traits from a large European cohort. MR-Egger regression, weighted median estimation, and inverse variance weighting all provided statistical insights into causality. Sensitivity analyses assessed the heterogeneity and pleiotropy among the genetic instruments used.
Results: MR analysis identified a causal relationship between taurine levels and 10 immunocyte phenotypes, with taurine found to be negatively and positively associated with three and seven phenotypes, respectively. Sensitivity analysis revealed no significant heterogeneity or pleiotropy, suggesting reliable MR findings.
Conclusion: This study provides insights into the immunological pathways by which taurine contributes to skin anti-aging effects, suggesting that increasing taurine levels could offer a novel strategy for anti-aging skincare.
KEYWORDS
anti-aging treatment, immune cells, Mendelian randomization, monocytes, taurine
1 | INTRODUCTION
Anti-aging of the skin is a crucial aim of many cosmetic treatments, as it can help improve the appearance and texture of the skin, slow down the skin aging process, and contribute to the restoration of skin health and youthfulness. Skin aging is significantly influenced by a variety of external factors, including ultraviolet radiation (UVR), particulate matter (PM), and the microbiome, which disrupt the skin
This article is excerpted from the Cosmetic Dermatology by Wound World.
