伤口世界
- 星期五, 14 1月 2022
一种可调节温湿度的防压疮吸氧面罩
摘 要：文章介绍一种可调节温湿度的防压疮吸氧面罩的改良与应用。此吸氧面罩包括防压疮气囊、可调节固定带、可调节温湿度装置、单向阀排气孔、干燥盒。防压疮气囊包括内环空腔层、透气减压层（纱布外层内为记忆海绵）、充气孔与挤压气囊。可调节温湿度装置包括蓄电池组件、温度调节器（内含加热管）与湿度调节器，且后端与缓冲座相连接。此吸氧面罩能有效防止患者长时间使用而引起面部皮肤损伤甚至溃疡，预防压疮的发生，也能改变氧气的温湿度，使患者吸入适宜的氧气，避免气道黏膜干燥，增加舒适感。同时，可固定调节带采用输液管材质，并使用魔术贴，方便使用，性价比高，易被患者所接受。
关键词：吸氧面罩；防压疮；可调节温湿度
- 星期四, 13 1月 2022
Custom-Molded Offloading Footwear Effectively Prevents Recurrence and Amputation, and Lowers Mortality Rates in High-Risk Diabetic Foot Patients: A Multicenter, Prospective Observational Study
Background: Recurrence of high-risk diabetic feet, after wound, healing is a common challenge among diabetic patients. Continuous use of an offloading device significantly prevents recurrence of high-risk diabetic feet, although patient adherence is imperative to ensuring this therapy’s clinical efficacy. In this study, we explored clinical outcomes of patients with a high-risk diabetic foot who had been prescribed with custom-molded offloading footwear under different adherence conditions.
Methods: A total of 48 patients (17 females and 31 males) with high-risk diabetic feet, who had been with prescribed offloading footwear in 13 medical centers across 4 cities, were enrolled in the current study. The patients were assigned into either continuous offloading therapy (COT, n = 31) or interrupted offloading therapy (IOT, n = 17) groups, according to their adherence to the therapy. All patients were followed up monthly, and differences in recurrence, amputation, and deaths between the groups were analyzed at 4 months after therapy.
Results: Forty-eight patients met our inclusion criteria and were therefore included in the final analysis. Among them, 31 were stratified into the COT group and adhered to offloading therapy throughout the study period, whereas 17 were grouped as IOT and exhibited interrupted adherence to offloading therapy. We found statistically significant differences in recurrence rates (0 vs 38.46%, p < 0.01), amputation (0 vs 11.76%, p < 0.01), and deaths (0% vs 5.88%, p < 0.01) between the groups during follow-up.
Conclusion: Patients’ adherence is imperative to efficacy of custom-molded offloading footwear during treatment of high-risk diabetic foot. Further studies are needed to elucidate the role of improved design of the offloading device and the need for enhanced patient education for improved adherence.
Keywords: custom-molded offloading footwear, high-risk diabetic foot, patient adherence
- 星期四, 13 1月 2022
Milk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis
Abstract:The refractory diabetic wound has remained a worldwide challenge as one of the major health problems. The impaired angiogenesis phase during diabetic wound healing partly contributes to the pathological process. MicroRNA (miRNA) is an essential regulator of gene expression in crucial biological processes and is a promising nucleic acid drug in therapeutic fields of the diabetic wound. However, miRNA therapies have limitations due to lacking an effective delivery system. In the present study, we found a significant reduction of miR-31-5p expression in the full-thickness wounds of diabetic mice compared to normal mice. Further, miR-31-5p has been proven to promote the proliferation, migration, and angiogenesis of endothelial cells. Thus, we conceived the idea of exogenously supplementing miR-31-5p mimics to treat the diabetic wound. We used milk-derived exosomes as a novel system for miR-31-5p delivery and successfully encapsulated miR-31-5p mimics into milk exosomes through electroporation. Then, we proved that the miR-31-5p loaded in exosomes achieved higher cell uptake and was able to resist degradation. Moreover, our miRNA-exosomal formulation demonstrated dramatically improved endothelial cell functions in vitro, together with the promotion of angiogenesis and enhanced diabetic wound healing in vivo. Collectively, our data showed the feasibility of milk exosomes as a scalable, biocompatible, and cost-effective delivery system to enhance the bioavailability and efficacy of miRNAs.
- 星期三, 12 1月 2022
Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches
Abstract: Wounds are among the most common skin conditions, displaying a large etiological diversity and being characterized by difffferent degrees of severity. Wound healing is a complex process that involves multiple steps such as inflflammation, proliferation and maturation and ends with scar formation. Since ancient times, a widely used option for treating skin wounds are plantbased treatments which currently have become the subject of modern pharmaceutical formulations. Triterpenes with tetracyclic and pentacyclic structure are extensively studied for their implication in wound healing as well as to determine their molecular mechanisms of action. The current review aims to summarize the main results of in vitro, in vivo and clinical studies conducted on lupane, ursane, oleanane, dammarane, lanostane and cycloartane type triterpenes as potential wound healing treatments.
Keywords: wound healing; pentacyclic triterpenes; tetracyclic triterpenes
- 星期二, 11 1月 2022
The Wound-Healing Effect of Mango Peel Extract on Incision Wounds in a Murine Model
Abstract: Mangifera indica can generate up to 60% of polluting by-products, including peels. However,it has been shown that flflavonoids and mangiferin are mainly responsible for the antioxidant, antiinflflammatory, and antibacterial activities closely related to the wound-healing process. The chemical composition of MEMI (methanolic extract of M. indica) was analyzed by HPLC-DAD, as well as concentrations of total phenol (TPC) and flflavonoids (TFC) and antioxidant activity (SA50). Wound healing effificacy was determined by measurements of wound contraction, histological analysis, and tensiometric method; moreover, anti-inflflammatory, antibacterial, and acute dermal toxicity (OECD 402) were also evaluated. Phenol, resorcinol, conjugated resorcinol, and mangiferin were detected. TPC, TFC, and SA50 were 136 mg GAE/g, 101.66 mg QE/g, and 36.33 µg/mL, respectively. Tensile strength and wound contraction closure did not show signifificant differences between MEMI and dexpanthenol groups. Histological analysis (after 14 days) shows a similar architecture between MEMI treatment and normal skin. MEMI exhibits a reduction in edema. Staphylococcus epidermidis had an MIC of 2 mg/mL, while Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli reached 4 mg/mL. The MEMI showed no signs of toxicity. Therefore, this study demonstrates multiple targets that flflavonoids and mangiferin of MEMI may present during the healing process.
Keywords: Mangifera indica peel; wound healing; antibacterial; antioxidant.
- 星期一, 10 1月 2022
Role of Honey in Advanced Wound Care
Abstract: Honey is a natural product rich in several phenolic compounds, enzymes, and sugars with antioxidant, anticarcinogenic, anti-inflflammatory, and antimicrobial potential. Indeed, the development of honey-based adhesives for wound care and other biomedical applications are topics being widely investigated over the years. Some of the advantages of the use of honey for wound-healing solutions are the acceleration of dermal repair and epithelialization, angiogenesis promotion, immune response promotion and the reduction in healing-related infections with pathogenic microorganisms. This paper reviews the main role of honey on the development of wound-healing-based applications, the main compounds responsible for the healing capacity, how the honey origin can inflfluence the healing properties, also highlighting promising results in in vitro and in vivo trials. The challenges in the use of honey for wound healing are also covered and discussed. The delivery methodology (direct application, incorporated in fifibrous membranes and hydrogels) is also presented and discussed.
Keywords: honey; wound-healing; antioxidant; antimicrobial; hydrogels; dermal repair; hydrogel
