内脏脂肪面积与2型糖尿病患者血管病变的相 关性研究进展

栾敬红* ，李社莉#

延安大学附属医院，陕西 延安

收稿日期：2022年1月16日；录用日期：2022年2月9日；发布日期：2022年2月18日

摘 要

在全球范围内2型糖尿病的患病率呈逐年上升趋势，目前我国糖尿病患病率达11.2% (WHO标准)或12.8% (ADA标准)。造成糖尿病大流行的原因是多方面的，包括人口老龄化、不健康饮食以及不良生活方式等。糖尿病及其慢性并发症带给患者及其家庭巨大的经济及心理负担，其中血管病变是最常见的糖尿病慢性并发症。有研究表示内脏脂肪与2型糖尿病的发生发展有关。内脏脂肪面积可能在糖尿病血管病变中起重要作用，通过研究两者关系，可以为临床早期防治糖尿病血管病变提供新思路。基于此，本文就内脏脂肪面积与2型糖尿病患者血管病变的相关性研究展开综述。

关键词：内脏脂肪面积，内脏脂肪组织，2型糖尿病，糖尿病血管病变

Progress in the Correlation between Visceral Fat Area and Vascular Lesions in Patients with Type 2 Diabetes

Jinghong Luan*, Sheli Li#

Yan’an University Affiliated Hospital, Yan’an Shaanxi

Received: Jan. 16th, 2022; accepted: Feb. 9th, 2022; published: Feb. 18th, 2022

Abstract

The prevalence of type 2 diabetes worldwide is increasing year by year. At present, the prevalence of diabetes in China is 11.2% (WHO standard) or 12.8% (ADA standard). The diabetes epidemic is driven by many factors, including ageing populations, unhealthy diets and poor lifestyles. Diabetes and its chronic complications bring enormous economic and psychological burden to patients and their families, among which vascular disease is the most common chronic complication of dietes. Studies have shown that visceral fat is related to the occurrence and development of type 2 diabetes. Visceral fat area may play an important role in diabetic vascular disease. The study of the relationship between the two can provide new ideas for early clinical prevention and treatment of diabetic vascular diseases. Based on this, this paper reviews the correlation between visceral fat area and vascular lesions in type 2 diabetes patients.

Keywords: Visceral Fat Area, Visceral Adipose Tissue, Type 2 Diabetes, Diabetic Vasculopathy

Copyright © 2022 by author(s) and Hans Publishers Inc.

This work is licensed under the Creative Commons Attribution International License (CC BY 4.0).

http://creativecommons.org/licenses/by/4.0/

糖尿病患者如何预防骨质疏松的研究进展

牛婷玉1* ，李小凤2#

1 西安医学院，陕西 西安

2 西安医学院附属陕西省人民医院，陕西 西安

收稿日期：2022年1月16日；录用日期：2022年2月9日；发布日期：2022年2月21日

摘 要

糖尿病(Diabetes)是一类以高血糖为特征可影响全身多个脏器和系统的慢性疾病，不仅使患者心血管、肾脏病等发病风险升高，也与骨质疏松的发生发展密切相关。骨质疏松一旦发生不可逆转，最终甚至演变为骨折的结局，给患者治疗和康复造成很大困难，因此早期预防至关重要。若能采取有效预防方法，就能降低糖尿病骨质疏松的患病率，减少患者痛苦、提高生活质量。本文主要就现阶段糖尿病患者如何预防骨质疏松的研究进展予以总结。

关键词：糖尿病，骨质疏松，预防方法

文章引用: 牛婷玉, 李小凤. 糖尿病患者如何预防骨质疏松的研究进展[J]. 临床医学进展, 2022, 12(2): 1178-1185.

DOI: 10.12677/acm.2022.122171

Research Progress on How to Prevent Osteoporosis in Diabetic Patients Tingyu Niu1*, Xiaofeng Li2#

1 Xi’an Medical University, Xi’an Shaanxi

2 Shaanxi Provincial People’s Hospital Affiliated to Xi’an Medical University, Xi’an Shaanxi

Received: Jan. 16th, 2022; accepted: Feb. 9th, 2022; published: Feb. 21st, 2022

Abstract

Diabetes is a chronic disease characterized by hyperglycemia that affects multiple organs and systems throughout the body. It not only increases the risk of cardiovascular and renal diseases, but also is closely related to the occurrence and development of osteoporosis. Once osteoporosis occurs irreversibly, it may even evolve into fracture, which causes great difficulties for the treatment and rehabilitation of patients. Therefore, early prevention is crucial. If effective prevention methods can be adopted, the prevalence of diabetic osteoporosis can be reduced, the pain of patients can be reduced, and the quality of life can be improved. This article mainly summarizes the research progress of how to prevent osteoporosis in diabetic patients at present.

Keywords：Diabetes Mellitus, Osteoporosis, The Prevention Methods

Copyright © 2022 by author(s) and Hans Publishers Inc.

This work is licensed under the Creative Commons Attribution International License (CC BY 4.0).

http://creativecommons.org/licenses/by/4.0/

Non-Diabetic Kidney Disease in Type 2 Diabetes Mellitus: A Study of 82 Patients and Review of the Literatures

Ehab Mohammed1, Issa Al Salmi1,2* , Dawood Al Riyami3, Saif Khan3, Marwa Al Riyami4, Fatma Al Rahbi1, Suad Hannawi5

1 The Renal Medicine Department, The Royal Hospital, Muscat, Oman

2 The Medicine Department, Oman Medical Specialty Board, Muscat, Oman

3 The Renal Medicine Department, SQUH, Muscat, Oman

4 The Pathology Department, SQUH, Muscat, Oman

5 The Medicine Department, MOHAP, Dubai, UAE

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How to cite this paper: Mohammed, E., Al Salmi, I., Al Riyami, D., Khan, S., Al Riyami, M., Al Rahbi, F. and Hannawi, S. (2022) Non-Diabetic Kidney Disease in Type 2 Diabetes Mellitus: A Study of 82 Patients and Review of the Literatures. Open Journal of Nephrology, 12, 169-186. https://doi.org/10.4236/ojneph.2022.121017

Received: February 25, 2022

Accepted: March 25, 2022

Published: March 28, 2022

Copyright © 2022 by author(s) and Scientific Research Publishing Inc.

This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/

Abstract

Background: Worldwide, diabetic nephropathy-DN is the leading cause of end-stage kidney disease-ESKD, DN is a common cause of renal failure with a reported frequency of 10% - 15% in type-2-diabetes-mellitus-T2DM patients, however there is a great discrepancy between countries. The aim of the present study is to evaluate the findings of kidney biopsies performed on diabetic patients.

Materials and Methods: We studied native kidney histopathological findings in the period from January 2016 till end of December 2018 done for patients with T2DM with chronic kidney diseases-CKD.

Results: A total of 82 DM-patients, 50 males (61%) and 32 females (39%) with age mean (95% CI) of 50.8 (47.1 - 55.2) years for all patients, ranged between 15 to 65 years. Histological findings showed that 57.3% of patients had DN. While focal-segmental-glomerulosclerosis-FSGS was present in 20.7%—primary in 8.6% and secondary in 12.1%. IgA represented 4.9%, while Lupus nephritis, Membranous and drug induced interstitial nephritis were each present in 3.7%. MCD was present in 2.4%. Lastly diffuse proliferative GN, ANCA associated glomerulonephritis, and hypertensive nephrosclerosis accounted for 1.2%.

Conclusion: The prevalence of NDKD is remarkably frequent in DM patients who underwent kidney biopsy and FSGS was the most frequent diagnosis. To get a proper histopathological diagnosis, an adequate tissue biopsy is needed with an adequate number of glomeruli. There is a great need for more consideration to biopsy diabetic patients, as the finding of NDKD requires a different therapeutic approach. This, hopefully, will help to manage these patients better and therefore, ameliorate the progression to ESKD over time and therefore delay the need for RRT.

Keywords

Diabetic Nephropathy, Diabetic Kidney Disease, Histopathology, Light Microscopy, Electron Microscopy, Immunofluorescence, Non-Diabetic Kidney Diseases, Renal Replacement Therapy (RRT)

Clinical application of traditional Chinese medicine powder in the treatment of acute and chronic wounds

Fu-Lei Li1 | Gao-Chao Wang2 | Bu-Qiang Wu1

1 Department of General Surgery, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China

2 Changzhi Medical College, Changzhi, China

Correspondence

       Bu-Qiang Wu, MD, Department of General Surgery, Heping Hospital Affiliated to Changzhi Medical College, No. 110, Yan'an South Road, Changzhi, 046000, Shanxi Province, China. Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Abstract

      This study aimed to explore the clinical application and efficacy of traditional Chinese medicine (TCM) powder in the treatment of acute and chronic wounds. Eighty patients with a wound infection were randomly and equally divided into a control group and an observation group. Gauze padding containing furacilin was used to dress the infected wounds of the control group. TCM powder was used to treat the wounds of the observation group. The total response rate of the observation group was significantly higher than the control group (P = .017). The colour and exudate volume scores in the observation group were lower than the control group, and the differences between the two groups were statistically significant (P < .05). The time to the appearance of new epithelium and time to the wound healing of the burns in the observation group were shorter than the control group, and the differences were statistically significant (P < .05). The TCM powder absorbed a large amount of necrotic tissue and exudate from the wound surface, cleared heat and toxins, and activated blood circulation. It also resolved blood stasis, eliminated pus, and allowed for new skin growth, as well as regenerating muscle.

KEYWORDS ：burn depth, burns, scalds, traditional Chinese medicine powder, wound surface

Key Messages

• the use of traditional Chinese medicine powder has certain advantages over the conventional Western medicine treatment of wounds as it is noninvasive and relatively cheap

• it has been shown to heal all types of burns, including third-degree burns, and is effective for treating ulcers, such as those found in diabetic foot

• it has also been successful in healing wounds that conventional treatment could not

Effects of Common Myokines on Diabetes Mellitus

Yu Zhu1,2*, Qingqing Liu1*, Yurong Zhu1*, Tiantian Guo1, Mengtong Jin1, Jiali Hao1, Chao Qi1, Xiaofeng Miao1, Duan Xi1, Jiamao Fan1#, Jin Li2

1 Linfen Central Hospital, Linfen, China

2 Beijing Sport University, Beijing, China

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How to cite this paper: Zhu, Y., Liu, Q.Q.,Zhu, Y.R., Guo, T.T., Jin, M.T., Hao, J.L.,Qi, C., Miao, X.F., Xi, D., Fan, J.M. and Li, J. (2022) Effects of Common Myokines on Diabetes Mellitus. Journal of Diabetes Mellitus, 12, 153-166. https://doi.org/10.4236/jdm.2022.123013

Received: February 17, 2022

Accepted: June 14, 2022

Published: June 17, 2022

Copyright © 2022 by author(s) and Scientific Research Publishing Inc.

This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/

Abstract

Diabetes mellitus, a type of chronic metabolic disease, is occurring more frequently and causes severe threats to human health. In vivo, exercise can stimulate skeletal muscle cells to secrete and release myokines into blood circulation, which will participate in metabolism and act on multiple organs or systems. Recently, the relationship between myokines and diabetes mellitus was a hot research topic, and myokines may be potential targets for the diagnosis, monitoring, prevention and treatment of diabetes mellitus. In this review, we elucidated the multiple effects of common myokines in the pathogenesis and therapy of diabetes mellitus, which will provide a theoretical foundation of the mechanism in the positive effects of exercises on humans.

Keywords: Diabetes, Myokines, Islet Cells, Insulin Resistance

Effects of Diabetes Mellitus upon Sperm Quality Insight into Molecular Level

Anna Papadopoulou*, Petros Karkalousos, Maria Trapali

Laboratory of Chemistry, Biochemistry, Cosmetic Science, University of West Attica, Athens, Greece

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How to cite this paper: Papadopoulou, A., Karkalousos, P. and Trapali, M. (2022) Effects of Diabetes Mellitus upon Sperm Quality Insight into Molecular Level. Journal of Diabetes Mellitus, 12, 75-86.

https://doi.org/10.4236/jdm.2022.122008

Received: January 10, 2022

Accepted: April 16, 2022

Published: April 19, 2022

Copyright © 2022 by author(s) and Scientific Research Publishing Inc.

This work is licensed under the Creative Commons Attribution International License (CC BY 4.0).

http://creativecommons.org/licenses/by/4.0/

Abstract

      Diabetes Mellitus is a chronic disease that affects important body organs in a very serious manner. The consequences of this disease turn out to be a significant problem for the patient, who tries to cope with the new condition his organism has been placed in. The most common effect of the disease, hyperglycaemia, leads over time to serious damage to various body systems, such as nerves and blood vessels. What is not widely known among the population is that diabetes may have harmful effects on the reproductive system of the men suffering from diabetes type 1 and 2 and that such a parameter could lead to or might be the reason for infertility problems for couples, for example, miscarriage or embryonic failure. AGEs is a number of products which are believed to play an important role, because their presence has been detected in increased level in diabetic men. This implies that those glycation products might play a key role in diabetic complications. Their receptor, RAGE, member of the immunoglobulin superfamily has been detected in the reproductive tract of diabetic men. Reactive oxygen species (ROS), a possible product of AGEs appear in high levels in seminal plasma and are believed to be the cause of DNA fragmentation. The objective of this review was to gather all the available material i.e. studies on diabetes mellitus in one article, to study the research which has already been conducted and the conclusions that have been drawn, in order to offer, if possible, new pathways and perspectives to the scientists, who focus on fertility problems, sometimes intractable.

Keywords

Diabetes, Nuclear Fragmentation, Sperm Quality, ROS, Sperm Motility, Sertoli Cells, RAGE, Sperm Structure, Gene Expression