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Anti-Melanogenic Effect of Dendropanax morbiferus and Its Active Components via Protein Kinase A/Cyclic Adenosine Monophosphate-Responsive Binding Protein- and p38 Mitogen-Activated Protein Kinase-Mediated Microphthalmia−Associated Transcription Fact

This article is excerpted from the 《Frontiers in Pharmacology》 by Wound World

Plant and Microalgae Derived Peptides Are Advantageously Employed as Bioactive Compounds in Cosmetics

This article is excerpted from the 《Frontiers in Plant Science》 by Wound World

Facial Contrast Is a Cross-Cultural Cue for Perceiving Age

This article is excerpted from the《Frontiers in Psychology》 by Wound World

Novel Rotational Combination Regimen of Skin Topicals Improves Facial Photoaging: Efficacy Demonstrated in Double-Blinded Clinical Trials and Laboratory Validation

This article is excerpted from the 《Frontiers in Medicine》 by Wound World

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Comparative evaluation of efficacy of 0.2% sodium hypochlorite (Hi Wash) mouthwash with 0.2% chlorhexidine mouthwash on plaque‑induced gingivitis: A clinical trial 2026-09-02 00:00

Rohit Mishra, Kabbur Thippanna Chandrashekar, Vandana Dubey Tripathi, Anushree Hazari, Blessy Shin Sabu, Anurag Sahu

Abstract:

Background: Bleeding gums are one of the common complaints to visit a dentist. Mechanical removal of plaque alone is not sufficient for the reduction of gingival inflammation associated with plaque. Mouthwashes are supplemented to it as a homecare product. The objective of this study is to evaluate the efficacy of 0.2% sodium hypochlorite mouthwash on plaque and gingival inflammation and to assess the clinical parameters of gingivitis patients from baseline to 21 days with the use of 0.2% sodium hypochlorite and 0.2% chlorhexidine mouthwashes.

Materials and Methods: This clinical trial study included 60 patients with gingival inflammation evaluated using clinical parameters such as bleeding on probing index, plaque index, and gingival index at baseline and 21 days. Group A patients were given Hi Wash mouthwash and Group B 0.2% chlorhexidine mouthwash with 30 patients in each group. Results: The scores for clinical parameters were significantly reduced after 21 days in Group A and Group B patients, and there was a reduction in plaque‑associated gingival inflammation without scaling and root planning.

Conclusions: 0.2% sodium hypochlorite mouthwash is as effective as 0.2% chlorhexidine for the treatment of gingivitis as it is an adjunct to mechanical plaque removal in terms of safety, less side effects, less staining and can be used as a routine mouthwash.

Key words:

0. 2% sodium hypochlorite, 0.2% chlorhexidine, gingivitis
Hydrogen-rich electrolyzed water is a useful mouthwash due to its biofilm-control properties: an in vitro and in vivo study 2026-09-01 00:00

Ha-Young Youn^1,*, Ji-Hye Kim^1,*, Min-Jeong Cho¹ , Su-Hyung Hong² , Eun-Kyong Kim¹

¹ Department of Preventive Dentistry, School of Dentistry, Kyungpook National University, Daegu, Korea

² Department of Oral Microbiology and Immunology, School of Dentistry, Kyungpook National University, Daegu, Korea

Background: Previous studies have demonstrated the inhibitory effect of hydrogen-rich water on biofilm formation. However, hydrogen-rich electrolyzed water (HEW) has not been evaluated as mouthwash, despite being economical, convenient, and biologically safe. We assessed the antibiofilm effects of HEW on Streptococcus mutans and its potential as a mouthwash.

Methods: The effect of HEW on S. mutans growth was assessed by measuring bacterial colony-forming units, and biofilm formation capacity was examined by crystal violet staining after culturing on a polystyrene plate. The effect of HEW on biofilm formation-related gene expression in S. mutans was assessed by real-time polymerase chain reaction. Finally, the effect of HEW on salivary S. mutans and plaque maturation was evaluated in 24 participants; after gargling with HEW twice daily, the salivary S. mutans count was quantified using a Caries Risk Test bacteria kit (Ivoclar Vivadent AG), and plaque maturation was compared using quantitative light-induced fluorescence imaging.

Results: Exposure to HEW resulted in no significant changes in S. mutans growth but a significant reduction in biofilm formation in vitro (p<0.001). Furthermore, the gene expression of glucosyltransferases (gtfB, gtfC) was significantly lower than that in the control group treated with tap water (p<0.05, p<0.01). S. mutans counts and plaque maturation were significantly lower in participants who gargled with HEW than in those who gargled with tap water (p<0.01).

Conclusion: Our data suggest that oral rinsing with HEW exerts antibiofilm effects on S. mutans, indicating that it can be used as a mouthwash to treat dental biofilm-dependent diseases.

Keywords: Biofilms; Dental caries; Electrolysis; Hydrogen; Mouthwashes
Antibacterial efficacy of a pH-neutral electrolyzed super-oxidized solution for nonsurgical periodontal treatment 2026-08-31 00:00

Cynthia Carolina Gonz-alez-Cantú ^a , Angel Torres-Mu -noz ~ ^a , Víctor Hugo Urrutia-Baca ^b,**, Gustavo Adolfo S-anchez-García ^a , Myriam Ang-elica De La Garza-Ramos ^a,*

^a Autonomous University of Nuevo Le-on, Center for Research and Development in Health Sciences (CIDICS), General Odontology and Specialties. Dr. Aguirre Pequeno and ~ Silao St, Mitras Centro, 64460, Monterrey, Nuevo Leon, Mexico

^b Autonomous University of Nuevo Le-on, School of Biological Sciences. the Immunology and Virology Laboratory. Pedro de Alba and Manuel L. Barragan St, Ciudad Universitaria, 66450, San Nicolas de Los Garza, Nuevo Leon, Mexico

ABSTRACT

Objective: Mouthwash is effective in maintaining oral hygiene in patients; however, there is concern that it may adversely affect human oral mucosa. We evaluated a pH-neutral electrolyzed super-oxidized solution (ESS, tradename OxOral®) combined with dental scaling in periodontitis patients. This longitudinal study was conducted with 34 patients divided into three groups. The control group treated with scaling plus saline, the second with scaling plus ESS mouthwash, and another with scaling plus ESS mouthwash and gel. The plaque index (PI), gingival index (GI), and probing depth (PD) were determined before and after periodontal treatment. Results: The final PI and GI decreased compared with the initial measurements in the three treatment groups (p < 0.05). Scaling plus ESS mouthwash and gel significantly reduced the final PI, GI, and DP compared to the control group (p < 0.05). Conclusion: Our study shows the antiseptic properties of ESS with mouthwash and gel. Further studies are needed to verify the results.

ARTICLE INFO

Keywords: Adjuvant；Antiseptic ；Dental scaling and root planning；Mouthwash；Periodontal treatment

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

文献精选

Anti-Melanogenic Effect of Dendropanax morbiferus and Its Active Components via Protein Kinase A/Cyclic Adenosine Monophosphate-Responsive Binding Protein- and p38 Mitogen-Activated Protein Kinase-Mediated Microphthalmia−Associated Transcription Fact

Plant and Microalgae Derived Peptides Are Advantageously Employed as Bioactive Compounds in Cosmetics

Facial Contrast Is a Cross-Cultural Cue for Perceiving Age

Novel Rotational Combination Regimen of Skin Topicals Improves Facial Photoaging: Efficacy Demonstrated in Double-Blinded Clinical Trials and Laboratory Validation

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Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

文献精选

Anti-Melanogenic Effect of Dendropanax morbiferus and Its Active Components via Protein Kinase A/Cyclic Adenosine Monophosphate-Responsive Binding Protein- and p38 Mitogen-Activated Protein Kinase-Mediated Microphthalmia−Associated Transcription Fact

Plant and Microalgae Derived Peptides Are Advantageously Employed as Bioactive Compounds in Cosmetics

Facial Contrast Is a Cross-Cultural Cue for Perceiving Age

Novel Rotational Combination Regimen of Skin Topicals Improves Facial Photoaging: Efficacy Demonstrated in Double-Blinded Clinical Trials and Laboratory Validation

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