Alfredo E. Hoyos，MDD；Mauricio E. Perez Pachon，MDD; Matt Stefanelli，MD；Mariana Borras Osorio, MD； Justo Calderon Mendoza，MSc；Maria Paula Castiblanco，MD；Mateo Leon Machicado，MD；and Andres Pinzon Valero，MD
AbstractBackground: Despite the general safety of liposuction and fat grafting procedures，surgical-site infections (SSIs) remain a significant concern. These infections, ranging from minor to severe，can arise from various sources and pose a substantial burden. The overuse of antibiotics has led to increased antimicrobial resistance，highlighting the need for alternative infection prevention strategies like stabilized hypochlorous acid (s-HOCl). Objectives: The aim of the authors of this study is to evaluate the efficacy and safety of s-HOCl in preventing SSIs following liposculpture and other body contouring procedures. Methods: A prospective cohort study and matched control cohort were conducted at a single plastic surgery center in Bogota，Colombia (Dhara Clinic). Adult patients scheduled for liposculpture and fat grafting from January 2020 to December 2023 formed the intervention group，receiving s-HOCl as a washing solution for adipose grafts. A matched control cohort was drawn from patients who underwent similar procedures from January 2017 to December 2019 without s-HOCl. Data on demographics，surgical characteristics，and SSI outcomes were collected and analyzed. Results: A total of 1008 patients were included，with 502 in the s-HOCl group and 506 in the control group. The infection rate in the s-HOCl group was 0.2 per 100 grafted muscles, compared with 0.54 in the control group. Relative risk of SSIs in the s-HOCl group was 0.4，indicating a reduction in infection rates. The small absolute risk reduction of 0.59% underscores the clinical importance，considering SSIs, although rare，are severe and life-threatening events，with significant impact on outcomes and healthcare costs. A reduction in the severity of infection and the level of required treatment was also observed. Conclusions: s-HOCl demonstrated potential to reduce SSI risk following liposuction and fat grafting. This intervention offers a valuable alternative to antibiotics，effectively reducing infection rates and contributing to improved patient outcomes and public health in postantibiotic era.
王昳娜1，何振华1，周瑾1，孙晓芬2
1.绍兴文理学院元培学院，浙江 312000；2.浙江中医药大学附属第二医院
Research progress on the application of hypochlorous acid in wound care
WANG Yi'na，HE Zhenhua，ZHOU Jin，SUN Xiaofen
Shaoxing University，Yuanpei College，Zhejiang 312000 China
Keywords hypochlorous acid solution；wound；infection；bacterial biofilm；clinical application；review
摘要 介绍了次氯酸溶液的发展史、杀菌机制、特点、与其他伤口清洁消毒剂的比较、使用方法以及当前研究的不足，旨在为次氯酸
溶液在伤口治疗、护理中的应用提供依据。
关键词 次氯酸溶液；伤口；感染；细菌生物膜；临床应用；综述
伤口世界平台生态圈，以“关爱人间所有伤口患者”为愿景，连接、整合和拓展线上和线下的管理慢性伤口的资源，倡导远程、就近和居家管理慢性伤口，解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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