Michael Gold MD FAAD¹ | Yoon-Soo Cindy Bae MD FAAD² | David J. Goldberg MD JD FAAD^3,4 | Sumayah Jamal MD PhD⁵ | Amy B. Lewis MD⁶ | Shari Marchbein MD FAAD⁷ | Adriana Ros DO⁸ | Uma Santhanam PhD⁹ | Lisa DiNatale^9,10 | Jaime Emmetsberger PhD^9,10

田潇雨 卢娜

中国药科大学，中国·江苏 南京 210000

摘 要

衰老(Senecence)是细胞功能逐渐退化的一种状态，在这种状态下细胞几乎丧失复制能力，并且细胞周期抑制基因p16INK4a 的表达升高。细胞衰老贯穿生物个体的整个生命过程，在各种生理以及病理过程中发挥重要的作用。一方面，衰老的细胞能够促进胚胎发育，伤口愈合和宿主免疫反应以及抑制肿瘤发生发展等。另一方面，随着年龄增长而在体内积累的衰老细胞也会对机体带来有害的影响。这些不能增殖的细胞产生衰老相关分泌表型(Senescence-Associated Secretory PhenotypeSASP)，促进衰老相关疾病(Aging-related Diseae)的发生发展，而清除衰老细胞能够减缓衰老相关疾病的症状。因此寻找能够特异性杀死衰老细胞的药物(Senolytics)成为了抗衰老领域的研究重点。

关键词
细胞衰老;衰老相关分泌表型;衰老相关疾病;抗衰老;Senolytics

Advances in Research on Senescence in Health and Diseases

Xiaoyu Tian Na Lu

China Pharmaceutical University, Nanjing, Jiangsu, 210000, China

AbstractSenescence is a state in which the cell's functional characteristics are gradually deteriorating, in which the cell is at a sustained lowevel ofreplication and is accompanied by an increase in the expression of the cell cycle inhibitor pl6lNK4a The production of senescent cells occurs throughout life and plays key roles in various physiological and pathological proceses. These noneproliferating celsoccupy key cellular niches and produce senescence-associated secretory phenotype (SASP) which contributes to aging-related diseasesprogress. Therefore, the search for Senolytics has become the focus ofresearch in the field of anti-aging.

Keywords
cellular senescence, SASP, aging-related disease, anti-senescence, senolytics

刘淼  叶俊儒
(成都医学院第一附属医院，成都610000)
【摘要】研究抗衰老是当今社会的热点课题。干细胞是具有自我更新能力和多向分化能力的细胞,间充质干细胞包含其中。研究常用的间充质干细胞有骨髓间充质干细胞和脂肪间充质干细胞,二者均在组织修复和抗衰老方面有广泛的应用,有很好的发展前景。本文综述了近年来脂肪间充质干细胞抗衰老作用的特点、机制及应用研究进展。

【关键词】干细胞;骨髓间充质干细胞;脂肪间充质干细胞;抗衰老;组织修复【中图分类号】R725【文献标识码】A【文章编号】1005-1457(2017)04-30-7

Advances in the Theoretical Research of Mesenchymal Stem Cells

Liu Miao Ye Junru

( The first affiliated hospital ofchengdu medical college ,chengdu 610000 , China)
Research on aging is a hot topic in today's society, Mesenchymal stem cells is a kind of stem cells, hasAbstraettheability to self-renewal and multi-directional differentiation potential, Research between commonly used there arebone marrow mesenchymal stem cells and adipose mesenchymal stem cells, mesenchymal stem cells between both intissue repair and anti-aning has a wide range of applications, In this paper,the characteristics,mechanism and applica-tion of the anti-aging effect of adipose mesenchymal stem cells in recent years are reviewd.

【Key words】Stem Cells; Bone Marrow mesenchymal stem cells; Adipose Mesenchymal stem cells; Ant- Aging; Tissue repair

章 晾

（武汉美莱医疗美容整形医院，湖北 武汉，430000）

【摘 要】 目的 探讨应用手术和非手术联合治疗方案恢复眼周年轻化的临床管理概念。方法 综合分析患者眼周衰老临床表现，选择上睑松弛矫正术、眼袋整形术等手术治疗方案联合肉毒素、玻尿酸、光电治疗等非手术治疗方案进行个性化的治疗。

结果 患者 22 例，术后回访 3-18 个月，眼周年轻化联合治疗方案越全面效果满意度越高。结论 应针对眼周衰老制定个性化联合治疗方案，达到眼周年轻化的目的。

【关键词】眼周年轻化；眼整形术；肉毒素；透明质酸；单极射频

DOI：

The clinical management of the combined treatment of peri-orbital rejuvenation ZHANG Liang (Mylike Cosmetic Hospital, Hubei Province, 430000, China)

[ABSTRACT] Objective To explore the concept of clinical management in the application of combined surgical and non-surgical treatment to restore the peri-orbital rejuvenation. Methods The clinical manifestations of peri-orbital aging were analyzed comprehensively, and surgical treatment (Blepharoplasty and Eyebag surgery ) combined with non-surgical treatment was selected. Non-surgical treatment includes: Botulinum toxin injection , Laser therapy (Radio frequency ; Picosecond) and Microneeding therapy. Results 22 patients were followed up for 3-18 months. The more comprehensive the treatment, the higher the satisfaction. Conclusion It is necessary to make a Personalized combination therapy for peri-orbital aging, so as to achieve the goal of peri-orbital

[KEY WORDS] peri-orbital rejuvenation; Blepharoplasty; botulinum toxin; hyaluronic acid; monopolar radiofrequency