Haixia Qi1 · Tao Zhang2 · Lijie Hou3 · Qi LI4 · Ruiping Huang3 · Lihua Ma1,3
Received: 23 December 2024 / Accepted: 29 March 2025 / Published online: 19 April 2025 © The Author(s) 2025, corrected publication 2025
Abstract
Objective This study aimed to comprehensively review the latest advancements in diabetic foot risk prediction models over the past four years to address the severe challenges posed by diabetic foot ulcers, which are among the leading causes of disability and mortality among diabetic patients. Diabetic foot ulcers are characterized by their complex aetiology, pose a grave threat to life and impose enormous social and economic burdens, thus becoming a critical issue in public health that urgently requires attention. By accurately predicting the risk of diabetic foot and implementing early intervention strategies, this study aimed to reduce its incidence and mortality rates.
Methods This study employed a systematic review and comprehensive analysis framework, conducted extensive searches of electronic databases (including PubMed, EMBASE, the Cochrane Library, CNKI, etc.) and supplemented these searches with manual literature collection to ensure comprehensive information coverage. During the literature screening and evalua-tion phase, strict adherence to the predetermined inclusion and exclusion criteria was maintained to guarantee the high qual-ity of the included studies. Further detailed quality assessments, data extraction, and analysis of the selected literature were conducted, with a focus on exploring the construction strategies of risk prediction models, the selection of key variables, the evaluation indicators of model performance, and the validation methods.
Results By comparing and analysing the differences among studies in terms of methodology, model effectiveness, and prac-tical application potential, this study summarized the development trends of diabetic foot risk prediction models and antici-pated future research directions. These findings indicate that with the assistance of advanced diabetic foot risk prediction models, potential risk factors can be identified and addressed early on, thereby effectively reducing the incidence of diabetic foot and significantly improving patients’ quality of life.
Conclusion This study revealed that diabetic foot risk prediction models have significant effects on accurately identifying risk factors and guiding early interventions, serving as effective tools to reduce the incidence of diabetic foot. Through early identification and intervention, the prognosis and quality of life of patients can be significantly improved, providing impor-tant references and guidance for the field of public health.
Keywords Diabetic foot ulcer · High-risk diabetic foot · Diabetes · Prediction model
Gabriele Angelo Vassallo1 · Tommaso Dionisi2,3 · Vittorio De Vita4 · Giuseppe Augello1 ·Antonio Gasbarrini3,5 · Dario Pitocco6 · Giovanni Addolorato2,3
Received: 25 January 2025 / Accepted: 29 March 2025 / Published online: 19 April 2025 © The Author(s) 2025
Fecal microbiota transplantation (FMT) has emerged as a potential therapeutic strategy for modulating gut dysbiosis in diabetes mellitus. This review critically evaluates preclinical and clinical evidence on FMT in type 1 (T1D) and type 2 dia-betes (T2D). Studies suggest that FMT can restore microbial diversity, improve glycemic control, and modulate immune responses, with varying effects across diabetes subtypes. In T1D, preclinical models demonstrate that FMT influences regulatory T-cell expansion and β-cell preservation, though clinical translation remains limited. In T2D, FMT has shown transient improvements in insulin sensitivity, with sustained effects observed only in patients with specific microbiome signatures. However, heterogeneity in patient responses, donor variability, and methodological limitations complicate its clinical application. This review highlights the interplay between FMT, immune modulation, and microbial metabolism, advocating for phenotype-stratified trials and multi-omics integration to enhance therapeutic precision.
Keywords Fecal microbiota transplantation · Intestinal Microbiome · Diabetes · Insulin sensitivity · Metabolic syndrome · Beta-cell
Abbreviations
FMT Fecal microbiota transplantation TUDCA Tauroursodeoxycholic acid VEGF Vascular endothelial growth factor SCFAs Short-chain fatty acids MMTT Mixed meal tolerance test FVT Fecal virome transplantation OGTT Oral glucose tolerance test SRB Sulfate-reducing bacteria LSI Lifestyle intervention
原创：伤口治疗及造口护理中心
下肢静脉性溃疡，俗称“老烂腿”，是下肢静脉疾病的常见临床表现。下肢静脉性溃疡常常反复发作，溃疡久治不愈，严重影响患者的正常生活，因此一旦出现下肢静脉性溃疡的现象，患者应该及时到正规医院的血管外科就医，以查清病因，对症下药.
下肢静脉性溃疡，俗称“老烂腿”，是下肢静脉疾病的常见临床表现。下肢静脉性溃疡常常反复发作，溃疡久治不愈，严重影响患者的正常生活，因此一旦出现下肢静脉性溃疡的现象，患者应该及时到正规医院的血管外科就医，以查清病因，对症下药。
今天我们来了解一下下肢静脉的基本机构及特点。
糖尿病足是糖尿病后期最严重的并发症之一，据文献统计，糖尿病足的发病率在糖尿病住院病人中约占15%的比例，糖尿病鞋是针对糖尿病足的保护专门研发设计的新型健康鞋，其合适的选材与科学的做工，可有效保护糖尿病足的患者。
足部是糖尿病这个多系统疾病的一个复杂的靶器官。糖尿病患者因周围神经病变与外周血管疾病合并过高的机械压力，可引起足部软组织及骨关节系统的破坏与畸形形成，进而引发一系列足部问题，从轻度的神经症状到严重的溃疡、感染、血管疾病、Charcot关节病和神经病变性骨折。如果积极治疗不能充分解决下肢出现的症状和并发症，则会造成灾难性的后果。因此，在糖尿病患者中开展对足部问题的早期预防和治疗将有重要的意义。
伤口世界平台生态圈，以“关爱人间所有伤口患者”为愿景，连接、整合和拓展线上和线下的管理慢性伤口的资源，倡导远程、就近和居家管理慢性伤口，解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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