Allyson N. Hamilton1 · Sahaana Chandran1 · Christopher A. Baker1,2 · Kristen E. Gibson1
Received: 2 December 2022 / Accepted: 13 January 2023 / Published online: 21 January 2023
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023
Abstract
Indirect contact with contaminated surfaces is a potential transmission route for COVID-19. Therefore, it is necessary to investigate convenient and inexpensive surface sanitization methods, such as HOCl, against severe acute respiratory syn-drome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 surrogate, Phi6 (~7 log PFU/mL), was prepared in artificial saliva and tripartite matrices, spot inoculated on coupons of either stainless steel or vinyl, and allowed to dry. The coupons were sprayed with either 500 ppm or 1000 ppm HOCl, and remained on the surface for 0 s (control), 5 s, 30 s, or 60 s. Samples were enumerated via the double agar overlay assay. Statistical analysis was completed in R using a generalized linear model with Quasipoisson error approximations. Time, concentration, surface type, and inoculum matrix were all significant contributors to log reduction at P=0.05. Significant three-way interactions were observed for 1000 ppm, vinyl, and 60 s (P=0.03) and 1000 ppm, tripartite, and 60 s (P=0.0121). A significant two-way interaction between vinyl and 60 s was also observed (P=0.0168). Overall, increased HOCl concentration and exposure time led to increased Phi6 reduction. Notably, the highest estimated mean log reduction was 3.31 (95% CI 3.14, 3.49) for stainless steel at 60 s and 1000 ppm HOCl in artificial saliva, indicating that this method of sanitization may not adequately reduce enveloped viruses to below infective thresholds.
Keywords Fomite · Phi6 · Hypochlorous acid · Vinyl · Stainless steel
Kyu-Il Lee1 , Yu-Kyeong Yun2 , Seung-Kyu Han2,3 , Kyung-Chul Moon2,3 , Sik Namgoong2,3 ,
Seong-Ho Jeong3 , Eun-Sang Dhong3
1Department of Plastic Surgery, Taean Public Health Office, Taean, Korea
2Diabetic Wound Center and Department of Plastic Surgery, Korea University Guro Hospital, Seoul, Korea
3Department of Plastic Surgery, Korea University College of Medicine, Seoul, Korea
Background: Adequate tissue oxygenation is a key determinant of diabetic foot ulcer (DFU) outcomes. Though transcutaneous oxygen pressure (TcPO2) is the gold standard for evaluating tissue oxygenation, its limited availability restricts routine clinical use. Consequently, toe pressure is frequently utilized as a practical surrogate; however, the direct correlation between these two modalities has yet to be rigorously investigated. This study aimed to assess the correlation and agreement between TcPO2and toe pressure in patients with DFUs.
Methods: A retrospective review was conducted on 837 DFU patients who received simultaneous TcPO2and toe pressure assessments.
The correlation between the two tests was analyzed using the Pearson correlation coefficient, and agreement was evaluated using Bland– Altman analysis. To aid interpretation, a scatterplot and Bland–Altman plot were generated.
Results: TcPO2and toe pressure demonstrated a strong correlation (R=0.66; 95% confidence interval, 0.62 to 0.70; P<0.001). Bland–
Altman analysis showed a mean bias of 26.9 mmHg (standard deviation of differences, 28.8 mmHg; 95% limits of agreement, −28.9 to 82.6 mmHg) between toe pressure and TcPO2, reflecting limited agreement and increased variability at higher perfusion levels.
Conclusion: TcPO2and toe pressure are strongly correlated. However, they are not interchangeable, particularly in DFU patients with high tissue perfusion.
Keywords: Diabetic foot; Foot ulcer; Ischemia; Microcirculation
原创： 十六点五 中山二院糖尿病足中心
IWGDF（The International Working Group on the Diabetic Foot）是一个以欧美从事糖尿病足工作的专家为主的，有其他大洲有关专家共同组成的，目前国际上有关糖尿病足的预防、诊断、治疗、研究、管理等方面最专业的国际组织之一（基本上没有之一）。
脓腔切开，3型安尔碘纱布填塞一天之后，重新打开伤口，进行第二次清创，这次清创也是非常重要的。一般需要完成三个任务：探查创面、鉴别坏死及感染的组织、仔细清除各种需要清除的组织。
（3）要把足部被细菌侵袭的各个空隙最好都能打开，尤其是足部比较重要的“空隙”，也是为了引流充分。
糖尿病足的创面清创术是最有效的局部抗菌治疗。毛主席很早之前就教导我们：扫把不到灰尘照例不会自己跑掉，糖尿病足清创术就是治疗糖尿病足局部创面上的“灰尘”（细菌）最有效的“扫把”。
糖尿病足创面难愈合的原因很多，但细菌感染是其中最重要的原因。
糖尿病足患者从开始愈合（到了红期，开始出现新的真皮的时候）到了完全愈合（主要是硬痂完全覆盖创面后）时，总是会出现创面附近、或者创面同边的足部，尤其是足背部、足踝部出现比较明显的肿胀，这种肿胀不伴有皮肤发红，但是有时会有触痛，一般没有波动感或有轻微的波动感
伤口世界平台生态圈，以“关爱人间所有伤口患者”为愿景，连接、整合和拓展线上和线下的管理慢性伤口的资源，倡导远程、就近和居家管理慢性伤口，解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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