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改良水胶体敷料对无痛结肠镜检查病人造口周围皮肤的影响

贾利军,贺亚楠,李向瑞,吴丽,袁雅卓,王贝贝,张淑利

Effects of hydrocolloid dressing on the peristomal skin in patients undergoing painless coonoSCOD1JA Liiun, HE Ya' nan, Ll Xiangrui, WU Li, YUAN Yazhuo, WANG Beibei, ZHANG Shuli(The First Affiliated Hospital of Zhengzhou University, Henan 450052 China)

Abstract Obiective: To explore the effects of modified hydrocolloid dressing ( HCD) on peristomal skin in painless colonoscopy patients.

Methods: A total of 64 patients with a stoma who underwent painless colonoscopy in the First Affiliated Hospital of Zhengzhou University from January 2022 to December 2022 were selected as the study subjects, and patients were divided into modified HCD application group(group H) and control group (group C) by random number table method,32 cases in each group Before the colonoscopy, group C implemented routine care, using a non-woven hole towel to cover the patient's abdomen; group Hused modified HCD(3M) to apply to the peristomal skin and perform colonoscopy. The grade of peristomal dermatitis(assessed by international wound evaluation standards), the percentage of peristomal skin moisture, the pH of the peristomal mucosa and the colony forming units (CFU) count of peristomal skin were observed

Results: After the intervention. the grade of peristomal dermatitis in group H was significantly better than that in group C, the CFU was significantly less than that in group C, and the percentage of skin moisture around the stoma was significantly lower than that in group C(all P<0.001), There was no significant statistical difference in skin temperature, and pH of the peristomal skin between the two groups after the intervention(P>0.05).

Conclusion: Modified HCD can provide reliable peristomal skin protection during painless colonoscopy.

Keywords hydrocolloid dressings: painless colonoscopy: peristomal dermatitis: potential of hvdrogen : colony forming unit

摘要目的:探讨改良水胶体敷料 (hydrocolloid dressing, HCD)对无痛结肠镜检查 (painless colonoscopy)病人造口周围皮肤 (peristomal skin)的影响。方法:选取2022年1月—2022年12月在郑州大学第一附属医院行无痛结肠镜检查的64例造口病人作为研究对象,采用随机数字表法分为改良 HCD应用组(H 组)和对照组(C组)各32例。在结肠镜检查前,C组实施常规护理,使用无纺布洞巾覆盖病人腹部;H 组在C组基础上采用改良 HCD(3M)粘贴于造口周围皮肤,实施结肠镜检查。观察两组病人造口周围性皮炎分级(采用国际伤口创面评价标准评估)、造口周围皮肤水分百分比、造口周围黏膜酸碱度(pH 值)和造口周围皮肤菌落计数。结果:干预后,H 组病人造口周围性皮炎分级明显优于 C组,菌落计数明显少于 C组,造口周围皮肤水分百分比明显低于 C组 (均P<0.001);干预后两组病人造口周围皮肤黏膜酸碱度和温度比较差异无统计学意义(P>0.05)。结论:在无痛结肠镜检查期间,改良 HCD可为病人提供可靠的造口周围皮肤保护作用。

关键词水胶体敷料;无痛结肠镜检查;造口周围性皮炎;酸碱度;菌落形成单位 doi:10.12104/ji.ssn.1674-4748.2023.16.004

作者简介贾利军,主管护师,硕士研究生在读,单位:450052,郑州大学第一附属医院;贺亚楠、李向瑞、吴丽、袁雅卓、王贝贝、张淑利(通讯作者)单位:450052,郑州大学第一附属医院。引用信息贾利军,贺亚楠,李向瑞,等.改良水胶体敷料对无痛结肠镜检查病人造口周围皮肤的影响[J].全科护理,2023,21(16):2176-2179.

K2 Content

异体表皮干细胞对裸鼠全层皮肤缺损创面移植异体全厚皮成活的影响及其机制 2024-11-22 00:00

黄韶斌 1 胡志成 1 张逸 2 唐冰 1 王鹏 1 徐海琳 1 王志勇 1 董云先 1 程璞 1 荣燕超 1 吴军 3 朱家源 1

1 中山大学附属第一医院烧伤科，广州 510080；

2 南通大学附属医院烧伤整形外科 226001；3 深圳大学第一附属医院烧伤整形科 518037 通信作者：朱家源，Email：该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Novel Cosmetic Ingredient CS-AA Polyion Complex and Skin Moisturizing Effect 2024-11-20 00:00

Hyungjoon Jeon Yong Won Shin Jong Gu Won Nojin Park Sang-Wook Park Nam Seo Son Mi-Sun Kim

LG Household & Health Care (LG H&H), LG Science Park R&D Center, Seoul, Republic of Korea

Correspondence: Hyungjoon Jeon (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。) Mi-Sun Kim (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)

Received: 29 January 2024

Revised: 21 June 2024

Accepted: 19 July 2024

Keywords: arginine | chondroitin sulfate | glutamine | skin hydration | TEWL | water-holding capacity

ABSTRACT

Purpose: The study explored the enhanced skin moisturizing capabilities and moisture retention effects achieved by forming a polyion complex using sulfated glycosaminoglycan (GAG), specifically chondroitin sulfate (CS), and amino acids (AA) such as glutamine (Q) and arginine (R). The overall hydration effect of this CS-AA complex was examined.

Methods: After analyzing the CS-AA polyion complex structure using spectroscopic methods, the ex vivo moisture retention ability was assessed under dry conditions using porcine skin samples. Additionally, the efficacy of the CS-AA polyion complex in reducing transepidermal water loss (TEWL) and improving skin hydration was evaluated on human subjects using a digital evaporimeter and a corneometer, respectively.

Results: Validating a systematic reduction in particle size, the following order was observed: CS > CS/AA simple mixture > CSAA complex based on dynamic light scattering (DLS) and transmission electron microscopy (TEM) analysis. Furthermore, observations revealed that the CS-AA complex exhibits negligible surface charge. Additionally, Fourier-transform infrared spectroscopy (FT-IR) analysis demonstrated a distinct peak shift in the complex, confirming the successful formation of the CS-AA complex. Subsequently, the water-holding effect through porcine skin was assessed, revealing a notable improvement in moisture retention (weight loss) for the CS-Q complex: 40.6% (1 h), 20.5% (2 h), and 18.7% (4 h) compared to glycerin. Similarly, the CS-R complex demonstrated enhancements of 50.2% (1 h), 37.5% (2 h), and 33% (4 h) compared to glycerin. Furthermore, TEWL improvement efficacy on human skin demonstrated approximately 25% improvement for both the CS-Q complex and CS-R complex, surpassing the modest 12.5% and 18% improvements witnessed with water and glycerin applications, respectively. Finally, employing a corneometer, hydration changes in the skin were monitored over 4 weeks. Although CS alone exhibited nominal alterations, the CS-Q complex and CS-R complex showed a significant increase in moisture levels after 4 weeks of application.

Conclusion: In this study, polyion complexes were successfully formed between CS, a sulfated GAG, and AA. Comparisons with glycerin, a well-known moisturizing agent, confirmed that the CS-AA complex exhibits superior moisturizing effects in various aspects. These findings suggest that the CS-AA complex is a more effective ingredient than CS or AA alone in terms of efficacy.
Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream 2024-11-19 00:00

Fan Yang1 Xinyuan Zhang2 Hua Wang1 Miao Guo1 Jinlong Zhang1 Xuejiao Feng3 Jiayi Yu3 Jiahui Yang3 Jinjin Zhu4 Yiyu Wang3

1 Research & Development Center, Mageline Biology Tech Co., Ltd, Wuhan, Hubei, China

2 Shanghai Skinshield Clinical Testing and Technological Research Ltd., Shanghai, China

3 Department of Dermatology, Air Force Medical Center, PLA, Beijing, China

4 Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China

Correspondence

Jinjin Zhu, Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, 430022, China.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Yiyu Wang, Department of Dermatology, Air Force Medical Center, PLA, Beijing, China.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Abstract

Background: The delicate periorbital region is susceptible to skin dehydration, wrinkles, and loss of elasticity. Thus, targeted and effective anti-aging interventions are necessary for the periorbital area.

Aim: To evaluate the efficacy and safety of a new anti-aging eye cream formulated with the active complex (Yeast/rice fermentation filtrate, N-acetylneuraminic acid, palmityl tripeptide-1, and palmitoyl tetrapeptide-7).

Methods: The cell viability and expressions of key extracellular matrix (ECM) components of the active complex were evaluated using a human skin fibroblast model. In the 12-week clinical trial, skin hydration, elasticity, facial photographs, and collagen density following eye cream application were assessed using Corneometer, Cutometer, VISIA, and ultrasound device, respectively. Dermatologists and participants evaluated clinical efficacy and safety at baseline, and after 4, 8, and 12 weeks.

Results: PCR and immunofluorescent analyses revealed that the active complex significantly stimulated fibroblast proliferation (p < 0.05) and markedly promote the synthesis of collagen and elastin. Clinical findings exhibited a substantial enhancement in skin hydration (28.12%), elasticity (18.81%), and collagen production (54.99%) following 12 weeks of eye cream application. Dermatological evaluations and participants’ assessments reported a significant improvement in skin moisture, roughness, elasticity, as well as fine lines and wrinkles by week 8.

Conclusion: The new anti-aging eye cream, enriched with the active complex, demonstrates comprehensive rejuvenating effects, effectively addressing aging concerns in the periorbital area, coupled with a high safety profile.

KEYWORDS anti-aging, collagen, elastin, extracellular matrix, eye cream, wrinkle

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

© 2024 The Author(s). Skin Research and Technology published by John Wiley & Sons Ltd.

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

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Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

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学术会议

伤口世界提示

改良水胶体敷料对无痛结肠镜检查病人造口周围皮肤的影响