Jolanta Szeliga-Krol1 · Agata Betlejewska1 · Monika Buraczynska1 · Wojciech Zaluska1
Received: 29 September 2025 / Accepted: 25 January 2026 © The Author(s) 2026
Abstract
Aims Our study aimed to evaluate the association between the erythropoietin gene rs1617640 polymorphism and diabetic retinopathy (DR) in diabetes patients.
Methods In this preliminary retrospective study the genotyping was performed on 860 DNA samples from Caucasian patients with type 2 diabetes mellitus (T2DM). For analyzing the effect of the polymorphism, patients were assigned into three phenotypic subgroups: non-DR (without retinopathy), NPDR (with non-proliferative diabetic retinopathy) and PDR (with proliferative diabetic retinopathy). The rs1617640 polymorphism was analyzed using polymerase chain reaction (PCR)–restriction fragment length polymorphism (RFLP) and direct DNA sequencing procedures.
Results A statistically significant difference in the polymorphism distribution was observed between T2DM patients with DR (both NPDR and PDR) and those without DR. The minor G allele was associated with the increased risk of DR. In the NPDR subgroup subjects carrying the G allele had 1.53-fold higher risk of developing retinopathy. Similarly, in the PDR subgroup patients carrying the G allele showed almost twofold increased risk of PDR in a dominant model of inheritance.
Conclusion Our results demonstrate that in T2DM patients the EPO rs1617460 polymorphism is associated with signifi-cantly increased risk of developing DR. This finding can provide a new insight into the role of EPO gene in the pathophysi-ology of microvascular complications of diabetes.
Keywords EPO gene · Type 2 diabetes mellitus · Diabetic retinopathy · Single nucleotide polymorphism · Risk allele
Communicated by Marta Letizia Hribal.
Monika Buraczynska 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
1 Department of Nephrology, Medical University of Lublin, Jaczewskiego 8, 20-950 Lublin, Poland
Andrea Tumminia1 · Raffaella Romano2 · Francesco Frasca1,3 · Francesco Galeano3 · Roberto Baratta1 · Vittorio Oteri3 · Alessia Longo3 · Lucia Frittitta3,4 · Rosario Le Moli5 · Tommaso Piticchio6 · Antonino Di Pino7 · Maurizio Di Marco7 · Luigi Piazza8 · Maria Carolina Picardo9 · Paola Magnano San Lio10 · Filippo Luca Fimognari11 · Marcello Romano2
Received: 13 November 2025 / Accepted: 5 February 2026 © The Author(s) 2026
Background Pain may be absent in a substantial proportion of elderly patients with acute abdominal conditions. This study explored the association between type 2 diabetes mellitus (T2DM) and asymptomatic presentation.
Methods We conducted a cross-sectional analysis of 215 patients aged≥65 years admitted with acute abdominal conditions. Demographic, clinical, and laboratory data were extracted from medical records. Descriptive statistics and multivariable logistic regression were used to identify associative predictors of asymptomatic acute abdomen (AAA).
Results The median age was 82 years [77–86]; 54.4% (n=117) were female; 31.2% (n=67) had T2DM. Overall, 33.5% (n=72) presented without abdominal pain. T2DM prevalence was higher in AAA than symptomatic patients (44.4% vs. 24.5%, p<0.01). In multivariable analysis, T2DM (OR 1.95, 95% CI 1.10–3.45, p=0.02), lower heart rate (OR 0.83, 95% CI 0.71–0.96, p=0.01), and absence of fever (OR 0.50, 95% CI 0.26–0.95, p=0.03) were associated with AAA. Among patients with T2DM, longer diabetes duration (12.5 years [10.5–14.5] vs. 8.8 years [5.0–11.0]; p<0.01) and higher HbA1c (8.2% [7.2–8.7] vs. 7.5% [6.8–7.6]; p=0.02) were associated with asymptomatic presentation.
Conclusions Asymptomatic acute abdomen is common among elderly patients. Long-standing and poorly controlled T2DM is associated with absent pain. Prospective studies are needed to clarify causal mechanisms, and early glyco-metabolic assessment may aid recognition of at-risk patients.
Keywords Type 2 diabetes · Acute abdomen · Elderly · Pain perception · Emergency medicine · Predictors
伤口世界平台生态圈，以“关爱人间所有伤口患者”为愿景，连接、整合和拓展线上和线下的管理慢性伤口的资源，倡导远程、就近和居家管理慢性伤口，解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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