伤口世界

电子邮件地址: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

星期三, 28 8月 2019

糖尿病足患者的营养支持治疗

原创：十六点五中山二院糖尿病足中心

糖尿病足的营养支持是糖尿病足最重要的治疗，甚至没有之一。

星期三, 28 8月 2019

在糖尿病足中用到极致的含碘消毒剂

原创：十六点五中山二院糖尿病足中心

碘是一种最古老的消毒剂，1811年法国药剂师库尔图利首次发现单质碘可以杀菌以来，有多种以碘为主要杀菌成分的消毒剂。

星期三, 28 8月 2019

糖尿病足脓肿和窦道的切开及清创

原创：十六点五中山二院糖尿病足中心

广义的清创包括脓腔或窦道的切开及除去创面或周围组织坏死的或无活性的组织及外来的异物，直到健康组织暴露出来为止，是医护工作人员的“三基”技能，应该被大部分医护人员掌握。狭义的清创仅仅包括用各种方法去除创面周边及其内部的坏死组织。

星期三, 28 8月 2019

糖尿病足清创技术

原创：DF 中山二院糖尿病足中心

清创是从伤口或周围组织除去坏死的或无活性的组织及外来的异物，直到健康组织暴露出来为止。

星期三, 28 8月 2019

糖尿病足负压引流

原创：DF 中山二院糖尿病足中心

糖尿病足负压引流：（Vacuum Assisted Closure, VAC）负压辅助创面愈合治疗技术是利用生物半透膜使开放创面封闭，使用专用负压机产生一定的负压，通过引流管和敷料作用于清创后的创面，是一种促进急慢性创面愈合的治疗方法。

星期三, 28 8月 2019

下肢血管介入手术

原创：DF 中山二院糖尿病足中心

下肢血管介入手术：糖尿病患者常伴有周围血管病变，尤其下肢动脉血管病变较为突出，是导致糖尿病足溃疡难以愈合的重要因素。

K2 Content

An evaluation of the effectiveness of ‘ULTRACOL 200′ in enhancing nasolabial fold wrinkles through cutaneous repair 2024-11-25 00:00

Nguyen Ngan Giang1,2 Hyun Ji Kim3 Pham Ngoc Chien2,3 Han Jin Kwon4 Jung Ryul Ham4 Won Ku Lee4 Yeon Ju Gu4 Shou Yi Zhou2,5 Xin Rui Zhang2,5 Sun Young Nam2 Chan Yeong Heo1,2,3,5

1 Department of Medical Device Development, College of Medicine, Seoul National University, Seoul, Republic of Korea

2 Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea

3 Korea Institute of Nonclinical Study, H&Bio. co. Ltd., Seongnam, Republic of Korea

4 UltraV Co., Ltd. R&D Center, Seoul, South Korea

5 Department of Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea

Correspondence Sun Young Nam and Chan Yeong Heo, Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 and 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Abstract

Background: Injectable filler, a nonsurgical beauty method, has gained popularity in rejuvenating sagging skin. In this study, polydioxanone (PDO) was utilized as the main component of the ULTRACOL200 filler that helps stimulate collagenesis and provide skin radiant effects. The study aimed to evaluate and compare the effectiveness of ULTRACOL200 with other commercialized products in visually improving dermatological problems.

Methods: Herein, 31 participants aged between 20 and 59 years were enrolled in the study. 1 mL of the testing product, as well as the quantity for the compared groups was injected into each participants face side individually. Subsequently, skin texture and sunken volume of skin were measured using ANTERA 3D CS imaging technology at three periods: before the application, 4 weeks after the initial application, and 4 weeks after the 2nd application of ULTRACOL200.

Results: The final results of skin texture and wrinkle volume evaluation consistently demonstrated significant enhancement. Consequently, subjective questionnaires were provided to the participants to evaluate the efficacy of the testing product, illustrating satisfactory responses after the twice applications.

Conclusion: The investigation has contributed substantially to the comprehension of a PDO-based filler (ULTRACOL200) for skin enhancement and provided profound insight for future clinical trials.

KEYWORDS collagen formation, filler, polydioxanone, skin enhancement, Ultracol200
异体表皮干细胞对裸鼠全层皮肤缺损创面移植异体全厚皮成活的影响及其机制 2024-11-22 00:00

黄韶斌 1 胡志成 1 张逸 2 唐冰 1 王鹏 1 徐海琳 1 王志勇 1 董云先 1 程璞 1 荣燕超 1 吴军 3 朱家源 1

1 中山大学附属第一医院烧伤科，广州 510080；

2 南通大学附属医院烧伤整形外科 226001；3 深圳大学第一附属医院烧伤整形科 518037 通信作者：朱家源，Email：该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Novel Cosmetic Ingredient CS-AA Polyion Complex and Skin Moisturizing Effect 2024-11-20 00:00

Hyungjoon Jeon Yong Won Shin Jong Gu Won Nojin Park Sang-Wook Park Nam Seo Son Mi-Sun Kim

LG Household & Health Care (LG H&H), LG Science Park R&D Center, Seoul, Republic of Korea

Correspondence: Hyungjoon Jeon (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。) Mi-Sun Kim (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)

Received: 29 January 2024

Revised: 21 June 2024

Accepted: 19 July 2024

Keywords: arginine | chondroitin sulfate | glutamine | skin hydration | TEWL | water-holding capacity

ABSTRACT

Purpose: The study explored the enhanced skin moisturizing capabilities and moisture retention effects achieved by forming a polyion complex using sulfated glycosaminoglycan (GAG), specifically chondroitin sulfate (CS), and amino acids (AA) such as glutamine (Q) and arginine (R). The overall hydration effect of this CS-AA complex was examined.

Methods: After analyzing the CS-AA polyion complex structure using spectroscopic methods, the ex vivo moisture retention ability was assessed under dry conditions using porcine skin samples. Additionally, the efficacy of the CS-AA polyion complex in reducing transepidermal water loss (TEWL) and improving skin hydration was evaluated on human subjects using a digital evaporimeter and a corneometer, respectively.

Results: Validating a systematic reduction in particle size, the following order was observed: CS > CS/AA simple mixture > CSAA complex based on dynamic light scattering (DLS) and transmission electron microscopy (TEM) analysis. Furthermore, observations revealed that the CS-AA complex exhibits negligible surface charge. Additionally, Fourier-transform infrared spectroscopy (FT-IR) analysis demonstrated a distinct peak shift in the complex, confirming the successful formation of the CS-AA complex. Subsequently, the water-holding effect through porcine skin was assessed, revealing a notable improvement in moisture retention (weight loss) for the CS-Q complex: 40.6% (1 h), 20.5% (2 h), and 18.7% (4 h) compared to glycerin. Similarly, the CS-R complex demonstrated enhancements of 50.2% (1 h), 37.5% (2 h), and 33% (4 h) compared to glycerin. Furthermore, TEWL improvement efficacy on human skin demonstrated approximately 25% improvement for both the CS-Q complex and CS-R complex, surpassing the modest 12.5% and 18% improvements witnessed with water and glycerin applications, respectively. Finally, employing a corneometer, hydration changes in the skin were monitored over 4 weeks. Although CS alone exhibited nominal alterations, the CS-Q complex and CS-R complex showed a significant increase in moisture levels after 4 weeks of application.

Conclusion: In this study, polyion complexes were successfully formed between CS, a sulfated GAG, and AA. Comparisons with glycerin, a well-known moisturizing agent, confirmed that the CS-AA complex exhibits superior moisturizing effects in various aspects. These findings suggest that the CS-AA complex is a more effective ingredient than CS or AA alone in terms of efficacy.

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

糖尿病足患者的营养支持治疗

在糖尿病足中用到极致的含碘消毒剂

糖尿病足脓肿和窦道的切开及清创

糖尿病足清创技术

糖尿病足负压引流

下肢血管介入手术

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

糖尿病足患者的营养支持治疗

在糖尿病足中用到极致的含碘消毒剂

糖尿病足脓肿和窦道的切开及清创

糖尿病足清创技术

糖尿病足负压引流

下肢血管介入手术

消息订阅

学术会议

伤口世界提示