伤口世界

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星期一, 14 10月 2019

同步报告病例1：TurboHawk斑块旋切系统开通股浅动脉支架闭塞病例（第二回）

原创：十六点五中山二院糖尿病足中心

不是各个病人都能非常顺利的完成治疗过程。

比如这个病人，我们迟迟未能发布他的第二回，是因为进展非常崎岖，而且，目前还在进行中。

患者2018年10月26日清创后，出血较多，晚间再次更换敷料后，出血基本停止。

星期一, 14 10月 2019

同步报告病例2：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过（第四回）

原创：十六点五中山二院糖尿病足中心

我们今天（2018年11月6日）打开了患者的负压，希望能够有我们想要的结果

星期一, 14 10月 2019

糖尿病足治疗的“三心”换来的成功：家庭糖尿病足护理病例之一

原创：十六点五中山二院糖尿病足中心

赖伯，2018年81岁，糖尿病史多年，2016年不幸伤到右足，经过几家医院反复转运，来到我院，期间发生“中风”、“消化道出血”、“心衰”等多种并发症，多次抢救之后，终于病情稳定，并在我院进行创面处理之后，达到下图的水平。

星期一, 14 10月 2019

同步报告病例2：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过（第三回）

原创：十六点五中山二院糖尿病足中心

星期一, 14 10月 2019

同步报告病例2：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过（第二回）

原创：十六点五中山二院糖尿病足中心

梁某，女，60岁，糖尿病病史7年，平时不规则用药，血糖控制一般。10余天前不小心刺伤左脚第2趾，到当地医院看病，感染扩散，当地医院建议截肢，患者要求转院于2018年10月27日转入我院。

星期一, 14 10月 2019

同步报告病例2：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过（第一回）

原创：十六点五中山二院糖尿病足中心

截肢与保肢只差一个中山二院的距离

K2 Content

Efficacy of probiotics in hair growth and dandruff control: A systematic review and meta-analysis 2024-11-28 00:00

Chang-Shik Yin a,1 , Trang Thi Minh Nguyen b,1 , Eun-Ji Yi b,c , Shengdao Zheng b,c , Arce Defeo Bellere b , Qiwen Zheng b , Xiangji Jin d , Myeongju Kim b , Sejic Park b , Sarang Oh b,c , Tae-Hoo Yi b,

a Acupuncture and Meridian Science Research Center, College of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea

b Graduate School of Biotechnology, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin, Republic of Korea

c Snowwhitefactory Co, Ltd., 807 Nonhyeon-ro, Gangnam-gu, Seoul, 06032, Republic of Korea

d Department of Pharmacology, School of Medicine, Kyung Hee University, 23 Kyungheedae-ro, Dong-daemun, Seoul, Republic of Korea

ABSTRACT

Background: Probiotics are intellectually rewarding for the discovery of their potential as a source of functional food. Investigating the economic and beauty sector dynamics, this study conducted a comprehensive review of scholarly articles to evaluate the capacity of probiotics to promote hair growth and manage dandruff.

Methods: We used the PRISMA 2020 with Embase, Pubmed, ClinicalTrials.gov, Scopus, and ICTRP databases to investigate studies till May 2023. Meta-analyses utilizing the random effects model were used with odds ratios (OR) and standardized mean differences (SMD).

Result: Meta-analysis comprised eight randomized clinical trials and preclinical studies. Hair growth analysis found a non-significant improvement in hair count (SMD = 0.32, 95 % CI -0.10 to 0.75) and a significant effect on thickness (SMD = 0.92, 95 % CI 0.47 to 1.36). In preclinical studies, probiotics significantly induced hair follicle count (SMD = 3.24, 95 % CI 0.65 to 5.82) and skin thickness (SMD = 2.32, 95 % CI 0.47 to 4.17). VEGF levels increased significantly (SMD = 2.97, 95 % CI 0.80 to 5.13), while IGF-1 showed a non-significant inducement (SMD = 0.53, 95% CI -4.40 to 5.45). For dandruff control, two studies demonstrated non-significant improvement in adherent dandruff (OR = 1.31, 95 % CI 0.13–13.65) and a significant increase in free dandruff (OR = 5.39, 95 % CI 1.50–19.43). Hair follicle count, VEGF, IGF-1, and adherent dandruff parameters were recorded with high heterogeneity. For the systematic review, probiotics have shown potential in improving hair growth and controlling dandruff through modulation of the immune pathway and gut-hair axis. The Wnt/β-catenin pathway, IGF-1 pathway, and VEGF are key molecular pathways in regulating hair follicle growth and maintenance.

Conclusions: This review found significant aspects exemplified by the properties of probiotics related to promoting hair growth and anti-dandruff effect, which serve as a roadmap for further in-depth studies to make it into pilot scales.

ARTICLE INFO

Keywords: Probiotic Hair loss Alopecia Hair growth Dandruff Scalp

* Corresponding author.

E-mail address: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (T.-H. Yi).

1 These authors contributed equally to this work.
Efficacy and safety of a cream containing panthenol, prebiotics, and probiotic lysate for improving sensitive skin symptoms 2024-11-27 00:00

Xianghua Zhang1 Delphine Kerob2 Zhongxing Zhang1 Han Tao1 Xiaofeng He3 Yi Yi3 Xiaofeng Fang3 Wenna Wang3 Andrew Steel3

1 L’Oreal Dermatological Beauty, L’Oréal China, Shanghai, China

2 La Roche-Posay Laboratoire Pharmaceutique, Levallois Perret, La Roche-Posay, France

3 Research and Innovation Center, L’Oréal China, Shanghai, China

Correspondence

Xianghua Zhang, L’Oreal Dermatological Beauty, L’Oréal China, Shanghai, China.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Abstract

Background: Sensitive skin is a common condition affecting a significant proportion of the population, and there is a growing demand for effective and safe management.

Aim: To evaluate the efficacy and safety of a cream containing panthenol, prebiotics, and probiotic lysate as an optimal care for facial sensitive skin.

Methods: A total of 110 participants (64 in group A and 46 in group B) with facial sensitive skin applied the cream twice daily for 28 days. Group A evaluated their sensitive skin, product efficacy, and product use experience at D0 (15 min), D1, D14, and D28. In group B, skin barrier function-related indicators were measured at baseline and on D1, D7, D14, and D28. Dermatologists evaluated tolerance for all participants.

Results: After 28 days of use, in group A, 100% of participants reported mildness and comfort with product use. Participants demonstrated significant improvements in skin barrier function-related indicators, including increased stratum corneum moisture content, reduced erythema index, elevated sebum content, decreased trans-epidermal water loss, and diminished skin redness parameter a* value (all p < 0.05). Dermatologist evaluations revealed excellent tolerance among all participants.

Conclusion: The panthenol-enriched cream with prebiotics and probiotic lysate exhibited substantial clinical efficacy in ameliorating facial sensitive skin conditions, coupled with a high safety profile.

KEYWORDS panthenol, prebiotics, probiotics, sensitive skin, skin barrier function
Changes in human skin composition due to intrinsic aging: a histologic and morphometric study 2024-11-26 00:00

Marta Arnal‑Forné1 · Tamara Molina‑García2 · María Ortega2 · Víctor Marcos‑Garcés2,3 · Pilar Molina4 · Antonio Ferrández‑Izquierdo1,2,5 · Pilar Sepulveda1,6,7 · Vicente Bodí2,3,6,8 · César Ríos‑Navarro1,2,6 · Amparo Ruiz‑Saurí1,2,6

Accepted: 10 June 2024 / Published online: 2 July 2024

© The Author(s) 2024

Abstract

Skin represents the main barrier against the external environment, but also plays a role in human relations, as one of the prime determinants of beauty, resulting in a high consumer demand for skincare-related pharmaceutical products. Given the importance of skin aging in both medical and social spheres, the present research aims to characterize microscopic changes in human skin composition due to intrinsic aging (as opposed to aging infuenced by external factors) via histological analysis of a photoprotected body region. Samples from 25 autopsies were taken from the periumbilical area and classifed into four age groups: group 1 (0–12 years), group 2 (13–25 years), group 3 (26–54 years), and group 4 (≥55 years). Diferent traditional histological (hematoxylin–eosin, Masson’s trichrome, orcein, toluidine, Alcian blue, and Feulgen reaction) and immunohistochemical (CK20, CD1a, Ki67, and CD31) stains were performed. A total of 1879 images photographed with a Leica DM3000 optical microscope were morphometrically analyzed using Image ProPlus 7.0 for further statistical analysis with GraphPad 9.0. Our results showed a reduction in epidermis thickness, interdigitation and mitotic indexes, while melanocyte count was raised. Papillary but not reticular dermis showed increased thickness with aging. Specifcally, in the papillary layer mast cells and glycosaminoglycans were expanded, whereas the reticular dermis displayed a diminution in glycosaminoglycans and elastic fbers. Moreover, total cellularity and vascularization of both dermises were diminished with aging. This morphometric analysis of photoprotected areas reveals that intrinsic aging signifcantly infuences human skin composition. This study paves the way for further research into the molecular basis underpinning these alterations, and into potential antiaging strategies.

Keywords Skin aging · Intrinsic aging · Morphometric analysis · Human biopsies

César Ríos-Navarro

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* Amparo Ruiz-Saurí 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

1 Department of Pathology, University of Valencia, Avda. Blasco Ibáñez 15. 46010, Valencia, Spain

2 Instituto de Investigación Sanitaria INCLIVA Biomedical Research Institute, Avda. Menéndez Pelayo 4acc,

46010 Valencia, Spain

3 Cardiology Department, Hospital Clínico Universitario, Valencia, Spain

4 Department of Pathology, Instituto de Medicina Legal y Ciencias Forenses, Valencia, Spain

5 Anatomic Pathology Department, Hospital Clínico Universitario, Valencia, Spain

6 Centro de Investigación Biomédica en Red (CIBER)-CV, Madrid, Spain

7 Regenerative Medicine and Heart Transplantation Unit, Instituto de Investigación Sanitaria La Fe, Valencia, Spain

8 Department of Medicine, University of Valencia, Valencia, Spain

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

同步报告病例1：TurboHawk斑块旋切系统开通股浅动脉支架闭塞病例（第二回）

同步报告病例2：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过（第四回）

糖尿病足治疗的“三心”换来的成功：家庭糖尿病足护理病例之一

同步报告病例2：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过（第三回）

同步报告病例2：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过（第二回）

同步报告病例2：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过（第一回）

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

同步报告病例1：TurboHawk斑块旋切系统开通股浅动脉支架闭塞病例（第二回）

同步报告病例2：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过（第四回）

糖尿病足治疗的“三心”换来的成功：家庭糖尿病足护理病例之一

同步报告病例2： 截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过（第三回）

同步报告病例2： 截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过（第二回）

同步报告病例2：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过（第一回）

消息订阅

学术会议

伤口世界提示

同步报告病例2：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过（第三回）

同步报告病例2：截肢截肢，激起一圈迷茫：一个标准糖尿病足患者的处理经过（第二回）