Hana Yamamoto, Nanami Shimomura and Yasushi Hasegawa
College of Environmental Technology, Muroran Institute of Technology, 27-1 Mizumoto, Muroran 050-8585, Japan; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (H.Y.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (N.S.)
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Abstract: Pearl oysters have been extensively utilized in pearl production; however, most pearl oyster shells are discarded as industrial waste. In a previous study, we demonstrated that the intraperitoneal administration of pearl oyster shell-derived nacre extract (NE) prevented d-galactose-induced brain and skin aging. In this study, we examined the anti-aging effects of orally administered NE in senescence-accelerated mice (SAMP8). Feeding SAMP8 mice NE prevented the development of aging-related characteristics, such as coarse and dull hair, which are commonly observed in aged mice. Additionally, the NE mitigated muscle aging in SAMP8 mice, such as a decline in grip strength. Histological analysis of skeletal muscle revealed that the NE suppressed the expression of aging markers, cyclin-dependent kinase inhibitor 2A (p16) and cyclin-dependent kinase inhibitor 1 (p21), and increased the expression of sirtuin1 and peroxisome proliferator-activated receptor gamma coactivator 1 (PGC1)- α, which are involved in muscle synthesis. These findings suggest that the oral administration of NE suppresses skeletal muscle aging. Moreover, NE administration suppressed skin aging, including a decline in water content. Interestingly, oral administration of NE significantly extended the lifespan of SAMP8 mice, suggesting that its effectiveness as an anti-aging agent of various tissues including skeletal muscle, skin, and adipose tissue.
Keywords: skeletal muscle aging; nacre extract; lifespan extension; sarcopenia; skin aging
Citation: Yamamoto, H.; Shimomura,
N.; Hasegawa, Y. Oral Administration
of Nacre Extract from Pearl Oyster
Shells Has Anti-Aging Effects on Skin
and Muscle, and Extends the Lifespan
in SAMP8 Mice. Pharmaceuticals 2024,
17, 713. https://doi.org/
10.3390/ph17060713
Academic Editors: Mariia Shanaida,
Geir Bjørklund and Olha
Mykhailenko
Received: 16 May 2024
Revised: 28 May 2024
Accepted: 29 May 2024
Published: 31 May 2024
This article is excerpted from the Nutrients 2024, 16, 2810 by Wound World.
Authors
Catherine R. Ratliff
David Strider
Maria Hendrika van Zuilen
Preetha Kamath
Juan Carlos Palacios
Li Wei
Yuting Bao
Qianwen Chai
Tuhina Banerjee
Arghya Das
Aradhana Singh
伤口世界平台生态圈，以“关爱人间所有伤口患者”为愿景，连接、整合和拓展线上和线下的管理慢性伤口的资源，倡导远程、就近和居家管理慢性伤口，解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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