Nguyen Ngan Giang1,2 Hyun Ji Kim3 Pham Ngoc Chien2,3 Han Jin Kwon4 Jung Ryul Ham4 Won Ku Lee4 Yeon Ju Gu4 Shou Yi Zhou2,5 Xin Rui Zhang2,5 Sun Young Nam2 Chan Yeong Heo1,2,3,5
1 Department of Medical Device Development, College of Medicine, Seoul National University, Seoul, Republic of Korea
2 Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea
3 Korea Institute of Nonclinical Study, H&Bio. co. Ltd., Seongnam, Republic of Korea
4 UltraV Co., Ltd. R&D Center, Seoul, South Korea
5 Department of Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea
Correspondence Sun Young Nam and Chan Yeong Heo, Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.
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Abstract
Background: Injectable filler, a nonsurgical beauty method, has gained popularity in rejuvenating sagging skin. In this study, polydioxanone (PDO) was utilized as the main component of the ULTRACOL200 filler that helps stimulate collagenesis and provide skin radiant effects. The study aimed to evaluate and compare the effectiveness of ULTRACOL200 with other commercialized products in visually improving dermatological problems.
Methods: Herein, 31 participants aged between 20 and 59 years were enrolled in the study. 1 mL of the testing product, as well as the quantity for the compared groups was injected into each participants face side individually. Subsequently, skin texture and sunken volume of skin were measured using ANTERA 3D CS imaging technology at three periods: before the application, 4 weeks after the initial application, and 4 weeks after the 2nd application of ULTRACOL200.
Results: The final results of skin texture and wrinkle volume evaluation consistently demonstrated significant enhancement. Consequently, subjective questionnaires were provided to the participants to evaluate the efficacy of the testing product, illustrating satisfactory responses after the twice applications.
Conclusion: The investigation has contributed substantially to the comprehension of a PDO-based filler (ULTRACOL200) for skin enhancement and provided profound insight for future clinical trials.
KEYWORDS collagen formation, filler, polydioxanone, skin enhancement, Ultracol200
黄韶斌 1 胡志成 1 张逸 2 唐冰 1 王鹏 1 徐海琳 1 王志勇 1 董云先 1 程璞 1 荣燕超 1 吴军 3 朱家源 1
1 中山大学附属第一医院烧伤科,广州 510080;
2 南通大学附属医院烧伤整形外科 226001;3 深圳大学第一附属医院烧伤整形科 518037 通信作者:朱家源,Email:该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
原创: 胡海涛 负压引流与创面修复
近日处理多位慢性伤口患者,他们的病程时间都大于五月,最长患者达六年,并且有相同的经历——换药、换药、换药,吃抗生素、抗生素、抗生素!
刘晗 负压引流与创面修复
是不是 瘘了?
原创: 十六点五 中山二院糖尿病足中心
男性,24岁,3年前外院诊断“下丘脑生殖细胞瘤”,进行γ刀治疗后,长期应用“氢化可的松”早晚各2片维持,半年前不慎损伤左小腿下部外侧皮肤,之后长期不愈合,收入院。
含银的敷料是目前治疗糖尿病足的主流敷料,有各种剂型,包括泡沫状、胶冻态、液态、粉末态、膏态等等,生产的厂家的非常多,其中的质量良莠不齐,很难鉴别。
进一步的清创就到了骨骼,对于骨髓炎最彻底的治疗方法就是去除被细菌侵袭的骨,正常的骨骼一般是浅黄色,如果发白或者变黑,往往就提示这段骨头可能活性比较差,另外,还有一种是面积比较大的骨暴露,一般的肉芽组织很难爬上去,因此,对于坏死的骨头及较大面积的骨暴露,一般需要清除。
皮下组织中的脂肪组织在足部分布广泛,而皮下脂肪中血管分布非常少,在相对或绝对缺血的糖尿病足中,脂肪组织边缘的是否出血不是其是否存活的可靠指标。
伤口世界平台生态圈,以“关爱人间所有伤口患者”为愿景,连接、整合和拓展线上和线下的管理慢性伤口的资源,倡导远程、就近和居家管理慢性伤口,解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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