A.Giaccari1 · G. Gliozzo1 · G. Ciccarelli1 · G. Di Giuseppe1 · C. Castellano2 · S. Cum3 · L. Delle Monache4,13 · M. Gallo5 ·M.Lastretti6 · G. Medea7 · M. Monesi8 · R. Napoli9 · B. Pintaudi10 · E. Succurro11 · G. Turchetti
Received: 9 January 2026 / Accepted: 17 March 2026 © The Author(s) 2026
Abstract
Background and aims Although continuous glucose monitoring (CGM) devices are now standard of care among Type 1 diabetes patients, they are still relatively underutilized in Type 2 diabetes (T2D), particularly in those patients not treated with insulin. Widespread adoption continues to be hindered by a combination of factors. Chief among these is the scarcity of long-term, large-scale clinical trials demonstrating the benefits of the use of CGM in T2D. This meta-analysis aimed to address this gap by comparing CGM with self-blood glucose monitoring (SBMG), with primary outcomes of HbA1c and time in range (TIR) in insulin-treated and non-insulin-treated TD2 patients.
Methods and results Following the stringent rules mandated by our National Health Service (which requires a panel com-posed of all stakeholders involved in diabetes treatment, and includes PICO, GRADE, AGREE, and meta-analyses), we performed a systematic review of RCTs that enrolled two groups of individuals with T2D, those treated with insulin (includ-ing basal and basal-bolus regimens), and those receiving treatments other than insulin. All included trials compared CGM with structured blood glucose monitoring (SBGM) with glycated hemoglobin (HbA1c) as the main endpoint. Based on the strength and consistency of the evidence, the panel issued a strong recommendation in favor of CGM for individuals with T2D treated with insulin (including those on basal insulin alone) and for individuals with T2D not treated with insulin, par-ticularly for those with glycated hemoglobin levels≥7%. From a pharmacoeconomic perspective, outcomes were positive in both patient groups.
Conclusion CGM represents a clinically effective and cost-efficient approach to optimizing glycemic control in T2D, becom-ing mandatory among individuals on insulin therapy. Our findings support a shift in clinical practice toward the more widespread use of CGM in T2D, with regulatory frameworks and reimbursement policies needing to adapt accordingly.
Keywords CGM · Type 2 Diabetes · Metanalysis · PICO · GRADE · Guidelines
Communicated by Massimo Federici, M.D.
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1 Center for Endocrine and Metabolic Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS and Università Cattolica del Sacro Cuore, Rome, Italy
2 Azienda USL of Modena, Sassuolo Hospital, Sassuolo, Italy
3 Diabetes and Diabetic Foot Care Unit, ASUGI, Monfalcone, Italy
4 National Board Member of FAND (Italian Association for the Rights of Diabetic People), Roma, Italy
5 Department of Endocrinology and Metabolic Diseases, AO SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
6 Order of Psychologists of Lazio, Rome, Italy
7 Italian Society of General Medicine (SIMG), Florence, Italy
8 Territorial Diabetology Unit, AUSL Ferrara, Ferrara, Italy
9 Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy
10 Diabetes Unit, Niguarda Cà Granda Hospital, Milan, Italy
11 Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy
12 Institute of Management, Scuola Superiore Sant’Anna, Pisa, Italy
13 Patient Advocacy Lab, ALTEMS – Università Cattolica del Sacro Cuore, Rome, Italy
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引用本文:简喜超, 简扬, 邓呈亮. 2025版《中国糖尿病足防治实践指南》解读[J]. 中华医学美学美容杂志, 2026, 32(2): 99-103. DOI: 10.3760/cma.j.cn114657-20251215-00266.
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Background: A decrease in blood circulation in diabetic foot ulcers (DFU) leads to a reduction in the angiogenesis process, macrophages function, neutrophils, and growth factors, which in turn slow the healing process. However, electrical muscle stimulation (EMS) can be used to stimulate the muscle that leads to the lower limbs, increasing local blood circulation. Aim: This study was conducted to identify changes in the ABI and the wound development score following EMS in DFUs. Methods: We used sequential sampling of respondents who met the inclusion criteria. The control group received standard wound care, while the intervention group received standard wound care plus EMS therapy. EMS intervention was performed for 4 weeks for 30 minutes per day. Result: The intervention group that received standard wound care plus the EMS had better-wound healing than the group that only received standard wound care. Conclusion: EMS can increase nitric oxide, which causes vasodilation of the blood vessels and stimulates cell synthesis and migration to the wound area.
Key words: ■Diabetic foot ulcer ■Electrical muscle stimulation (EMS) ■Nitric Oxide ■Veinoplus Arterial
Sukarni is a lecturer in the Department of Nursing Education, University of Tanjungpura, Pontianak, West Kalimantan, Indonesia; Hikmat Permana is an Internist of Hasan Sadikin Hospital Bandung, West Java; Chandra Isabella is a lecturer in the Department of Nursing Education, University of Padjadjaran, Bandung, West Java, Indonesia
JACQUI FLETCHER OBE Clinical Editor, Wounds UK
Author: Joyce Black
Joyce Black is Professor, College of Nursing, University of Nebraska Medical Center, Omaha, Nebraska, US
This meeting report is based on the Mölnlycke-sponsored workshop held at the sixth World Union of Wound Healing Societies (WUWHS) Congress on March 1–5, 2022, in Abu Dhabi, United Arab Emirates. The workshop, titled ‘Surgical incision care — negative pressure wound therapy and advanced dressings: what to use and when’, included presentations from Kylie Sandy Hodgetts, Rhidian Morgan-Jones and Amit Gefen. The topics of surgical dressings, risk assessment and requirements of closed-incision negative pressure wound therapy (ciNPWT) were all explored.
Authors:
Rhidian Morgan-Jones (Chair), Amit Gefen and Kylie Sandy-Hodgetts
Rhidian Morgan-Jones (Chair) is Consultant Orthopaedic Surgeon, Cardiff Knee Clinic, University Hospital Llandough, Cardiff, UK; Amit Gefen is Professor of Biomedical Engineering and the Herbert J. Berman Chair in Vascular Bioengineering, Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel; Kylie Sandy-Hodgetts is Associate Professor, Centre of Molecular Medicine & Innovative Therapeutics, Murdoch University; Senior Research Fellow, Director Skin Integrity Research Institute, School of Biomedical Sciences, University of Western Australia, Perth, Australia.
Abstract: Congenital dermal sinuses are a distinctive form of occult dysraphism where patients present with neurological compression, tethering, or meningitis. This is a case study of a child presenting with spina bifida with foot deformity and a chronic non-healing ulcer after excision of dermal sinus, and subsequent tethered cord due to arachnoiditis. He developed osteomyelitis and postoperatively, a non-healing ulcer, in an insensate foot. The patient was successfully managed, and complete wound healing was achieved within three months. A multidisciplinary approach to monitor, prevent and treat complications that may impact functionality, quality of life and survival of young patients with congenital dermal sinuses is needed.
Key words: ■ Congenital dermal sinus ■ Foot deformity ■ Insensate foot ■ Non-healing ulcer
Sunil V. Kari, Dr, MS, General Surgery, Sou. Mandakini Memorial Clinic, A unit of Mandakini Medi Engg Health Pvt Ltd, Bhagya plaza, NCM, Hubballi, India;
Vilasavati SS. Kanthi, Dr. MBBS, DCH, Sou. Mandakini Memorial Clinic, A unit of Mandakini Medi Engg Health Pvt Ltd, Bhagya plaza, NCM, Hubballi, India.
Wound care management has continued to evolve and considering the Medicare population (ages 65 and above), the implications of management are significant. In the Medicare population, chronic wounds rank among the topmost reasons for seeking care. One sixth of Medicare patients are affected by chronic wounds which takes a major toll economically and medically (Nussbaum et al, 2018). Platelet rich plasma (PRP) is an important aspect of management due to its regenerative properties and its ability to accelerate healing. Some researchers have opined that PRP has the unique ability to completely heal wounds, however, research findings are conflicting with regards to the outcomes based on the types of wounds such as pressure ulcers and venous ulcers. PRP is a combination of thrombocytes, cytokines and multiple growth factors which include, but are not limited to, Platelet-Derived Growth Factor, Fibroblast Growth Factor, Insulin Growth Factor, Vascular Endothelial Growth Factor, Transforming Growth Factor-β, and Hepatocyte Growth Factor. Owing to the growing need and concern for PRP, especially in the area of regulation and consistency of outcomes of treatment, the authors have presented an overview of this modality of wound care in the older population.
Veronica C Nwagwu is Clinical Assistant Professor, Division of Geriatric and Palliative Medicine, University of Michigan Medical School; Certified Wound Care Specialist Physician, Cochair Wound Prevention and Management SIG- American Geriatrics Society (AGS); Theodore Suh is Professor of Internal Medicine, Division of Geriatric and Palliative Medicine, University of Michigan Health System, Professor, GRECC Ann Arbor Veterans Affairs Hospital, US; Jerome Okudo is Researcher, Department of Public Health, University of Texas, Houston, Texas, US
伤口世界平台生态圈,以“关爱人间所有伤口患者”为愿景,连接、整合和拓展线上和线下的管理慢性伤口的资源,倡导远程、就近和居家管理慢性伤口,解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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