Marianna Blyumin-Karasik1 | Jessica Colon2 | Sophie Gaer1 | Isabella Vigil1 | Sylvie Nguyen2 | Jordan Rosen1
1 Precision Skin & Body Institute, Davie, Florida, USA | 2Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Davie, Florida, USA
Correspondence: Marianna Blyumin-Karasik (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)
Received: 12 May 2025 | Revised: 7 August 2025 | Accepted: 12 August 2025
Funding: The authors received no specific funding for this work.
Keywords: aesthetic | cosmeceuticals | hypochlorous acid | integrated skincare | laser treatment | photoaging | resurfacing laser
Carmine Piccolo1 · Sara de Candia1 · Annalisa Natalicchio1 · Sergio Di Molfetta1 · Irene Caruso1 · Luigi Laviola1 · Francesco Giorgino1 · Gian Pio Sorice
Received: 16 December 2025 / Accepted: 11 March 2026 © The Author(s) 2026
Abstract
Aims Phenylketonuria and type 1 diabetes are lifelong metabolic disorders requiring complex and potentially conflicting nutritional strategies. Their coexistence is rare, yet management may become particularly challenging during transition from pediatric to adult care. We describe the case of a young adult with phenylketonuria who developed type 1 diabetes.
Methods A 27-year-old man with longstanding phenylketonuria was referred to an adult metabolic-diabetes center after the diagnosis of type 1 diabetes. Clinical, biochemical, nutritional, and continuous glucose monitoring data were reviewed. The intervention included structured therapeutic education, transition from fixed insulin doses to a dynamic regimen based on carbohydrate counting, and revision of medical nutrition therapy using phenylketonuria-adapted low-protein foods and sugar-free phenylalanine-free amino acid supplements.
Results At diagnosis, HbA1c was 11.5%, with markedly reduced C-peptide levels and high titer anti-GAD antibodies. Ini-tial diabetes management was associated with poor adherence to the phenylketonuria diet, increased intake of conventional protein sources, and elevated phenylalanine levels. After individualized insulin titration and nutritional intervention, HbA1c improved from 11.5% to 7.8%, phenylalanine levels decreased from 842 to 705 μmol/L, insulin requirement declined from 0.55 to 0.3 IU/kg/day, and continuous glucose monitoring showed improved glycemic control without increased hypoglyce-mia. The Glycemia Risk Index improved from high-risk Zone E to low-intermediate-risk Zone B.
Conclusions This case highlights the need for personalized multidisciplinary care integrating continuous glucose monitor-ing, carbohydrate counting, and phenylketonuria specific nutrition to optimize both metabolic conditions.
Keywords Phenylketonuria · Type 1 diabetes · CGM · multidisciplinary approach
毕业于上海交通大学医学院，护理学硕士，创面治疗师。2010年起从事创面修复临床实践与研究，主要研究方向为慢性创面的护理与管理。现任上海交通大学医学院附属第九人民医院伤口、造口、压疮专业小组组长，中国医疗保健国际交流促进会糖尿病足病分会护理学组委员、中国医师协会显微外科医师分会伤口治疗师专业委员会委员。
护理学本科毕业，上海交通大学医学院附属瑞金医院烧伤科总带教、创面修复中心护理组长、创面治疗师、中国创面修复专科建设“1239”三年行动计划专家委员会委员。
上海交大医学院附属瑞金医院创面修复 创面治疗师 、上海市创面修复研究中心主管护师、中国医疗保健国际交流促进会创面修复与再生分会青年委员、全国创面修复专科联盟1239项目成员。
医学博士，教授、博士生导师，现任上海交通大学医学院科技发展处副处长、上海市烧伤研究所副所长。
现任解放军第三O四医院全军创伤修复重点实验室主任，全军烧伤研究所副所长兼基础研究部主任。主要领域涉及创伤弹道学、生长因子生物学、干细胞诱导分化与组织再生、严重创伤重要内脏缺血性损伤的主动修复与再生等长期从事创伤和创伤后。
原创：伤口、造口、失禁护理俱乐部
伤口世界平台生态圈，以“关爱人间所有伤口患者”为愿景，连接、整合和拓展线上和线下的管理慢性伤口的资源，倡导远程、就近和居家管理慢性伤口，解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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